Results 71 to 80 of about 355,717 (299)

Neuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.
Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni   +10 more
wiley   +1 more source

Olfactory function in focal epilepsies: Understanding mesial temporal lobe epilepsy beyond the hippocampus [PDF]

, 2019
Several lines of research have linked olfactory regions with the pathophysiology of focal epilepsies. Among those regions, the piriform cortex represents the major part of the primary olfactory cortex.
Aledo Serrano, Angel, Campo, Pablo, Espinosa Jovel, Camilo, García Morales, Irene, Gil Nagel, Antonio, Jiménez Huete, Adolfo, Toledano, Rafael   +6 more
core   +2 more sources

TBK1‐Associated Primary Lateral Sclerosis Followed by Right Temporal Variant Frontotemporal Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We report a 58‐year‐old woman with a novel splice‐site variant in the TANK‐binding kinase 1 (TBK1:c.993–2A>C p.Ala332TyrfsTer39) who sequentially developed primary lateral sclerosis (PLS) followed by right temporal variant frontotemporal dementia (rtvFTD). Neuroimaging demonstrated right anterior temporal atrophy before cognitive symptoms, and
Tomoyasu Matsubara, Naoki Kihara, Satoko Miyatake, Koji Fujita, Konoka Tachibana, Ryosuke Miyamoto, Hiroki Yamazaki, Yusuke Osaki, Nazere Keyoumu, Yuki Kuwano, Nobutoshi Morimoto, Suzuran Saito, Eriko Koshimizu, Yoichi Otomi, Kenji Ishibashi, Masafumi Harada, Naomichi Matsumoto, Hiroyuki Morino, Yuishin Izumi   +18 more
wiley   +1 more source

Association between temporal lobe P-glycoprotein expression and seizure recurrence after surgery for pharmacoresistant temporal lobe epilepsy

Neurobiology of Disease, 2010
Surgery is recommended for pharmacoresistant temporal lobe epilepsy (TLE), but seizures recur in approximately one third of patients postsurgery.
Patrick Kwan, Hiu Ming Li, Eman Al-Jufairi, Rawia Abdulla, Michael Gonzales, Andrew H. Kaye, Cassandra Szoeke, Ho Keung Ng, Ka Sing Wong, Terence J. O'Brien   +9 more
doaj   +1 more source

Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A [PDF]

, 2017
Epilepsy comprises several syndromes, amongst the most common being mesial temporal lobe epilepsy with hippocampal sclerosis. Seizures in mesial temporal lobe epilepsy with hippocampal sclerosis are typically drug-resistant, and mesial temporal lobe ...
Alhusaini, Saud, Becker, Albert, Becker, Felicitas, Berkovic, Samuel F., Blumcke, Ingmar, Buchfelder, Michael, Buono, Russell J., Catarino, Claudia B., Cavalleri, Gianpiero L., Chaves, João, Coras, Roland, Costa, Paulo P., da Silva, António M., Dahl, Hans-Henrik M., de Graan, Pierre N. E., Delanty, Norman, Depondt, Chantal, Doherty, Colin P., Dorn, Thomas, Duncan, Susan, Eriksson, Kai J., Gruber-Sedlmayr, Ursula, Hakonarson, Hakon, Hallmann, Kerstin, Hamer, Hajo M., Hansen, Jörg, Hessel, Ellen V. S., Hildebrand, Michael S., Kantanen, Anne-Mari, Kasperavičiūtė, Dalia, Kobow, Katja, Koeleman, Bobby P. C., Krämer, Günter, Kunz, Wolfram S., Kälviäinen, Reetta K., Leal, Bárbara, Lerche, Holger, Leu, Costin, Matarin, Mar, Meng Tan, K., Novy, Jan, O'Brien, Terence J., Pandolfo, Massimo, Paravidino, Roberta, Petrovski, Slave, Ramasamy, Adaikalavan, Reif, Philipp S., Reinthaler, Eva M., Robbiano, Angela, Rosenow, Felix, Ryten, Mina, Rössler, Karl, Scheffer, Ingrid E., Schlachter, Kurt, Schoch, Susanne, Silva, Berta M., Sisodiya, Sanjay M., Smith, Colin, Sperling, Michael R., Steinhoff, Bernhard J., Stogmann, Elisabeth, Striano, Pasquale, Théâtre, Emilie, Tostevin, Anna, Trabzuni, Daniah, von Lehe, Marec, Weale, Michael E., Weber, Yvonne, Zara, Federico, Zimprich, Fritz, Zumsteg, Dominik   +70 more
core  

FDG‐PET Associations With Disease Severity and Outcomes in NMDA‐Receptor IgG Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Patients with N‐methyl‐D‐aspartate (NMDA) receptor‐immunoglobulin G (IgG) autoimmune encephalitis (NMDAR‐IgG AE) demonstrate occipital lobe hypometabolism on baseline brain fluorodeoxyglucose‐positron emission tomography (bFDG‐PET).
Jonathan K. Lee, Jeffrey Lambe, Scott Johnson, Akua Abrah, Jennifer Bullen, Jeffrey A. Cohen, Tatchaporn Ongphichetmetha, Amy Kunchok   +7 more
wiley   +1 more source

Understanding liquid-jet atomization cascades via vortex dynamics [PDF]

, 2018
Temporal instabilities of a planar liquid jet are studied using direct numerical simulation (DNS) of the incompressible Navier-Stokes equations with level-set (LS) and volume-of-fluid (VoF) surface tracking methods.
Hussain, Fazle, Sirignano, William A., Zandian, Arash   +2 more
core   +2 more sources

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Seizure clusters in drug-resistant focal epilepsy. [PDF]

, 2016
We investigated clinical factors associated with seizure clustering in patients with drug-resistant focal epilepsy and any association between seizure clustering and outcome after surgery.
Asadi-Pooya, Asadi-Pooya, Bauer, Fong, Haut, Haut, Haut, Haut, Herzog, Spencer, Sperling, Tonini, Woolley   +12 more
core   +2 more sources

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li, Guilin Meng, Zijie Wang, Xiao Hu, Jing Cheng, Chu Chen, Tiannan Yang, Jiaxin Luo, Zizhen Meng, Xueyun Liu, Qi Li   +10 more
wiley   +1 more source