Results 51 to 60 of about 57,147 (307)

Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]

, 2014
Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core   +1 more source

The Tale of the Residual Tail: Insights From Continuous Intracranial Monitoring From Post‐Hippocampectomy Dynamics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Subtotal hippocampal resection can leave residual hippocampal tissue, yet the immediate postoperative electrophysiologic evolution of such remnants is unknown. We describe a patient with drug‐resistant temporal lobe epilepsy in whom a hippocampal remnant was continuously monitored using a responsive neurostimulator (RNS) following subtotal ...
Patrick Hartnett, Syeda Amrah Hashmi, Amaan Qureshi, Heather Spader, Shayan Moosa, Ifrah Zawar   +5 more
wiley   +1 more source

Neuroimaging in Pediatric Epilepsy

Brain Sciences, 2019
Pediatric epilepsy presents with various diagnostic challenges. Recent advances in neuroimaging play an important role in the diagnosis, management and in guiding the treatment of pediatric epilepsy.
Zakir Shaikh, Alcy Torres, Masanori Takeoka   +2 more
doaj   +1 more source

Epidemiology of Temporal Lobe Epilepsy [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2000
To fulfill its task of informed clinical decision making and resource allocation, epidemiological studies in epilepsy must adhere to a series of methodological standards. These are reviewed. Because seizure and epilepsy classification systems may be viewed as extensions of the diagnosis, they have direct implications in the acquisition and ...
openaire   +2 more sources

Cortical neuronal loss and hippocampal sclerosis are not detected by voxel-based morphometry in individual epilepsy surgery patients

, 2009
Voxel-based morphometry (VBM) has detected differences between brains of groups of patients with epilepsy and controls, but the sensitivity for detecting subtle pathological changes in single subjects has not been established.
Martinian, Lillian, Sisodiya, Sanjay M., John S. Duncan, Sisodiya, S.M., Mark R. Symms, Niels K. Focke, Eriksson, Sofia H., Sofia H. Eriksson, Lillian Martinian, Focke, N.K., Thom, M., Duncan, John S., Martinian, L., Duncan, J.S., Symms, Mark R., Thom, Maria, Symms, M.R., Maria Thom, Focke, Niels K., Eriksson, S.H., Sanjay M. Sisodiya   +20 more
core   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Recognition memory impairments in temporal lobe epilepsy: The contribution of recollection and metacognition [PDF]

, 2012
Temporal lobe epilepsy (TLE) is a complex neurological condition associated with a variety of memory problems. This thesis attempted to elucidate the nature and extent of memory impairments further in this clinical group by drawing on dual-process theory
Illman, Nathan Anthony
core  

The persistence of erroneous familiarity in an epileptic male : Challenging perceptual theories of déjà vu activation

, 2008
We report the case of a 39-year-old, temporal lobe epileptic male, MH. Prior to complex partial seizure, experienced up to three times a day, MH often experiences an aura experienced as a persistent sensation of deja vu.
Moulin, Christopher J. A., O'Connor, Akira Robert   +1 more
core   +1 more source

Doublecortin-expressing cell types in temporal lobe epilepsy [PDF]

, 2018
Doublecortin (DCX) is widely regarded as a marker of immature and migrating neurons during development. While DCX expression persists in adults, particularly in the temporal lobe and neurogenic regions, it is unknown how seizures influence its expression.
Liu, J.Y.W., Cheryl Reeves, Matarin, Mar, Reeves, Cheryl, McEvoy, A.W., Sisodiya, S.M., Joan Y. W. Liu, Matarin, M., Thompson, P., Thom, M., Reeves, C., Matarin, M, Miserocchi, Anna, Liu, JYW, Maria Thom, Thompson, Pamela, Miserocchi, A, McEvoy, AW, Miserocchi, A., Anna Miserocchi, McEvoy, Andrew W., Sisodiya, Sanjay M., Mar Matarin, Reeves, C, Thom, Maria, Sisodiya, SM, Thom, M, Pamela Thompson, Liu, Joan Y. W., Thompson, P, Andrew W. McEvoy, Sanjay M. Sisodiya   +31 more
core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source