Results 71 to 80 of about 1,239,914 (289)
Structural controllability of temporal networks
New Journal of Physics, 2014 The control of complex systems is an ongoing challenge of complexity research. Recent advances using concepts of structural control deduce a wide range of control related properties from the network representation of complex systems. Here, we examine the
Márton Pósfai, Philipp Hövel
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Eigenvector Centrality Measure Based on Node Similarity for Multilayer and Temporal Networks
IEEE Access, 2019 Centrality of nodes is very useful for understanding the behavior of systems and has recently attracted plenty of attention from researchers. In this paper, we propose a new eigenvector centrality based on node similarity for ranking nodes in multilayer ...
Laishui Lv +5 more
doaj +1 more source
Short-Term Memory in Orthogonal Neural Networks
, 2004 We study the ability of linear recurrent networks obeying discrete time dynamics to store long temporal sequences that are retrievable from the instantaneous state of the network.
Daniel D. Lee +5 more
core +1 more source
Navigability of temporal networks in hyperbolic space [PDF]
, 2017 Information routing is one of the main tasks in many complex networks with a communication function. Maps produced by embedding the networks in hyperbolic space can assist this task enabling the implementation of efficient navigation strategies. However,
Ortiz, Elisenda +2 more
core +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Random walks in non-Poissoinan activity driven temporal networks
New Journal of Physics, 2019 The interest in non-Markovian dynamics within the complex systems community has recently blossomed, due to a new wealth of time-resolved data pointing out the bursty dynamics of many natural and human interactions, manifested in an inter-event time ...
Antoine Moinet +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Network Diffusion Framework to Simulate Spreading Processes in Complex Networks
Big Data Mining and AnalyticsWith the advancement of computational network science, its research scope has significantly expanded beyond static graphs to encompass more complex structures.
Michał Czuba +7 more
doaj +1 more source