Results 41 to 50 of about 341,873 (266)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

From Ordinary to Extraordinary: The Crucial Role of Common Species in Desert Plant Community Stability with Arbuscular Mycorrhizal (AM) Fungi Under Increased Precipitation

Plants
Climate change is altering precipitation patterns in Central Asia’s arid zones, destabilizing desert ecosystems. Arbuscular mycorrhizal (AM) fungi, key soil microorganisms forming symbiosis with most plants, critically maintain ecosystem stability, yet ...
Zhanquan Ji, Qianqian Dong, Rong Yang, Wenhao Qin, Yi Peng, Yangyang Jia   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Temporal Stability of Plant Species α-Diversity in Alpine Grasslands of the Tibetan Plateau and Their Implications for Biodiversity Conservation

Agronomy
The temporal stability of alpine plant α-diversity remains poorly understood, constraining predictions of biodiversity dynamics. Here, this study examined spatiotemporal patterns in the temporal stability of plant α-diversity (species richness, Shannon ...
Tianyu Li, Wei Sun, Shaowei Li, Erfu Dai, Gang Fu   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Galerkin weighted residual approach to the stability analysis of hydromagnetic hybrid nanofluid flow past a convective heating stretching/shrinking surface

Journal of Taibah University for Science
Despite the importance of bifurcation analysis for controlling boundary layer separation and reducing drag force in aerodynamics and hydrodynamics, only a few mathematical methods have been explored in the literature.
Adeshina Taofeeq Adeosun, Abdul Rahman Mohd Kasim, Mojeed Taiwo Akolade, Yusuf Olatunji Tijani   +3 more
doaj   +1 more source

Temporal Stability of Lipid-Shelled Microbubbles During Acoustically-Mediated Blood-Brain Barrier Opening

Frontiers in Physics, 2020
Non-invasive blood-brain barrier (BBB) opening using focused ultrasound (FUS) is being tested as a means to locally deliver drugs into the brain. Such FUS therapies require injection of pre-formed microbubbles, currently used as contrast agents in ...
Antonios N. Pouliopoulos, Daniella A. Jimenez, Alexander Frank, Alexander Robertson, Lin Zhang, Alina R. Kline-Schoder, Vividha Bhaskar, Mitra Harpale, Elizabeth Caso, Nicholas Papapanou, Rachel Anderson, Rachel Li, Elisa E. Konofagou, Elisa E. Konofagou   +13 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Long-Term Production Performance and Stability of Alfalfa/Grass Mixtures in the Longdong Loess Plateau of China: Subjected to Various Species Combinations and Seeding Ratios

Agriculture
Stable productivity is the basis for efficient and sustainable use of perennial grasslands, holding both ecological and economic importance. Alfalfa-based mixtures have great potential to achieve this goal.
Xiaojuan Wu, Junyu Zhang, Jiaojiao Zhang, Yixiao Lu, Ting Ye, Huimin Yang   +5 more
doaj   +1 more source