Results 51 to 60 of about 3,887,366 (252)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A micro-perspective on variation and universals [PDF]

, 2017
This paper approaches the questions raised in the workshop description surrounding universals and variation from the perspective of microvariation. Throughout this document we frequently refer to van Craenenbroeck and van Koppen (2016) (henceforth VCVK),
van Koppen, J.M., van Craenenbroeck, Jeroen, LS BZ Variatielinguistiek vh Nederlands, ILS Variation   +3 more
core  

Partitioning the variation in stream fish assemblages within a spatio-temporal hierarchy [PDF]

, 2007
This paper describes the relative influence of (i) landscape scale environmental and hydrological factors, (ii) local scale environmental conditions including recent flow history, and (iii) spatial effects (proximity of sites to one another), on the ...
Arthington, Angela H., Arthington, Angela, D. Harch, Bronwyn, Stewart-Koster, Ben, Kennard, Mark J, Kennard, Mark J., Harch, Bronwyn, Pusey, Bradley J, Arthington, Angela H, Pusey, Bradley J., Sheldon, Fran, Kennard, Mark, Pusey, Bradley, Harch, Bronwyn D, Harch, Bronwyn D.   +14 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Terrestrial water storage change from temporal gravity variation [PDF]

, 2009
Recent progress in accurately monitoring temporal gravity variations by means of superconducting gravimeters and satellite geodesy provides unprecedented opportunities in closing the water balance.
Hasan, S.
core  

Factors controlling spatio-temporal variation in carbon dioxide efflux from surface litter, roots, and soil organic matter at four rain forest sites in the eastern Amazon [PDF]

, 2007
This study explored biotic and abiotic causes for spatio-temporal variation in soil respiration from surface litter, roots, and soil organic matter over one year at four rain forest sites with different vegetation structures and soil types in the eastern
da Costa, A. C. L., de Almeida, S. S., Meir, P., Aragao, L. E. O. C., Braga, A., de Athaydes, J., Metcalfe, D. B., Malhi, Y., Williams, M.; id_orcid, Goncalves, P. H. L.   +9 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Temporal Variation in Heat-Mortality Associations: A Multicountry Study. [PDF]

, 2015
BACKGROUND: Recent investigations have reported a decline in the heat-related mortality risk during the last decades. However, these studies are frequently based on modeling approaches that do not fully characterize the complex temperature-mortality ...
Petkova, Elisaveta, Tong, Shilu, Masahiro Hashizume, Aurelio Tobias, Gasparrini, Antonio, Patrick Kinney, Ben Armstrong, Guo, Yuming, Ho, Kim, Antonio Gasparrini, Zanobetti, Antonella, Elisaveta P. Petkova, Eric Lavigne, Petkova, Elisaveta P, Armstrong, Ben G, Armstrong, Ben, Shilu Tong, Hashizume, Masahiro, Joel D. Schwartz, Leone, Michela, Armstrong, Ben G., Yuming Guo, Schwartz, Joel, Schwartz, Joel D, Lavigne, Eric, Honda, Yasushi, Michela Leone, Ben G. Armstrong, Kinney, Patrick L., Tobias, Aurelio, Antonella Zanobetti, Joel Schwartz, Schwartz, Joel D., Kinney, Patrick L, Kinney, Patrick, Petkova, Elisaveta Plamenova, Patrick L. Kinney, Yasushi Honda, Petkova, Elisaveta P., Kim, Ho, Ho Kim   +40 more
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source