Results 31 to 40 of about 681,716 (312)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

The connection between classroom climate and emotions in educational context and their relationship with academic achievement

open access: yesInovacije u Nastavi
Based on Pekrun’s control-value theory, this paper examines the relationship between academic emotions and classroom climate. The aim of the research is to investigate the connection between classroom climate and emotions in teaching, as well as their ...
Dušan J. Ranđelović   +1 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

open access: yesFEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Comparative Evaluation of Accuracy of Milled Temporary Crowns using Metrology Software: An In vitro Study

open access: yesIndian Journal of Dental Sciences
Context: This study compared the accuracy of computer-aided design and computer-aided manufacturing (CAD/CAM) milled temporary dental crowns using Metrology software.
Rajesh Suhas Swami, Sayed M. Killedar
doaj   +1 more source

Comparative Study of Health-Related Quality of Life between Colorectal Cancer Patients with Temporary and Permanent Stoma

open access: yesSiriraj Medical Journal, 2019
Objective: To compare the health-related quality of life (HRQOL) between colorectal cancer (CRC) patients with temporary and permanent stoma. Methods: This survey was a cross-sectional study that was conducted on 110 CRC patients living with stoma.
Natharom Chutikamo, R.N.   +2 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Effect of different polishing methods on surface roughness of provisional prosthetic materials

open access: yesThe Journal of Indian Prosthodontic Society, 2018
Purpose: To evaluate the surface roughness of bis-acrylic and acrylic resins submitted to different methods of polishing. Materials and Methods: Fifty samples of each provisional restorative material (Structur 2, Protemp 4, Duralay, and Dencrilay) were ...
Ivian Verena Maia Tupinamba   +3 more
doaj   +1 more source

TEMPORARY " PILONS." [PDF]

open access: yesThe Lancet, 1917
n ...
openaire   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

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