Results 31 to 40 of about 106,410 (260)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Problems of Evaluation of Temporary Employment’s Influence on Injuries and Occupational Diseases

Соціальна економіка, 2018
In the article special attention is paid to the problems of estimating the effect of temporary employment on injuries and occupational diseases. The purpose of the research is to form theoretical and methodological basis for assessing the impact of ...
Yuliya Lazebnyk
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Organizing in the shadow of donors: How donations market regulates the governance practices of sponsored projects in non-governmental organizations

BAR: Brazilian Administration Review, 2019
The purpose of this study is to analyze the influence of donors in the organization of governance practices of sponsored projects in non-governmental organizations (NGOs) from an agency theory perspective.
Adonai José Lacruz, Ralf Luis de Moura, Alexandre Reis Rosa   +2 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Practopoietic Lens to Conceptualize Temporary Organizing

Singaporean Journal of Business Economics and Management Studies, 2018
The purpose of this paper is to conceptualize temporary organizing as a practopoietic system. We critically review the current conceptualizations of projects; from the traditional project management perspective, and the temporary organization perspective using a systems approach. By juxtaposing the characteristics of the project with a system, we argue
Dwivedula, Ravikiran, Bredillet, Christophe N., Müller, Ralf   +2 more
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Symptomatic treatment of acute respiratory viral infections

Медицинский совет, 2015
The most common causes of respiratory diseases are acute respiratory viral infections (ARVI). According to the World Health Organization, every adult suffers from ARVI twice a year, while an average child gets sick 3 times more often. Each year in Russia,
O. V. Goncharova, G. V. Kuranov
doaj   +1 more source

Operational Reliability in Complex Temporary Organizations

Proceedings of the 29th European Safety and Reliability Conference (ESREL), 2019
The complex interconnectivity characterizing a temporary organization (TO) increases the risk of adverse work situations emerging in unexpected ways. In TOs operating in a high-hazard environment - here referred to as complex temporary organizations (CTOs) - this may lead to disastrous consequences. Still many CTOs do not experience disasters.
Zuiderwijk, D.C., Boersma, F.K.
openaire   +2 more sources

Organizing the Usual Suspects: Structuring Temporary Organizations

Journal of Strategic Innovation and Sustainability, 2020
Temporary vertical groups shift boundary decisions from a make, buy, or ally choice by a single firm acting alone to a collaborative decision influenced by the entire group. Using archival data on bridge construction project networks, we apply traditional theories of the firm at the group level of analysis.
Samuel S. Holloway, Mark. R. Meckler
openaire   +2 more sources