Results 41 to 50 of about 7,028,046 (330)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Problems of Evaluation of Temporary Employment’s Influence on Injuries and Occupational Diseases
Соціальна економіка, 2018 In the article special attention is paid to the problems of estimating the effect of temporary employment on injuries and occupational diseases. The purpose of the research is to form theoretical and methodological basis for assessing the impact of ...
Yuliya Lazebnyk
doaj +1 more source
Practopoietic Lens to Conceptualize Temporary Organizing
Singaporean Journal of Business Economics and Management Studies, 2018 The purpose of this paper is to conceptualize temporary organizing as a practopoietic system. We critically review the current conceptualizations of projects; from the traditional project management perspective, and the temporary organization perspective using a systems approach. By juxtaposing the characteristics of the project with a system, we argue
Dwivedula, Ravikiran +2 more
openaire +2 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
BAR: Brazilian Administration Review, 2019 The purpose of this study is to analyze the influence of donors in the organization of governance practices of sponsored projects in non-governmental organizations (NGOs) from an agency theory perspective.
Adonai José Lacruz +2 more
doaj +1 more source
Operational Reliability in Complex Temporary Organizations
Proceedings of the 29th European Safety and Reliability Conference (ESREL), 2019 The complex interconnectivity characterizing a temporary organization (TO) increases the risk of adverse work situations emerging in unexpected ways. In TOs operating in a high-hazard environment - here referred to as complex temporary organizations (CTOs) - this may lead to disastrous consequences. Still many CTOs do not experience disasters.
Zuiderwijk, D.C., Boersma, F.K.
openaire +2 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Work organizational outcomes of the use of temporary agency workers
, 2012 This article examines work organizational dynamics in workplaces using temporary agency workers. Previous research has principally either emphasized one effect, the division into core and periphery, or criticized this effect.
Håkansson, Kristina, +1 more
core +1 more source
The COVID-19 Pandemic and International Trade: Temporary Turbulence or Paradigm Shift?
European Journal of Risk Regulation, 2020 The COVID-19 epidemic has taken the world by surprise. Initially, it was seen as a Chinese, and later South-East Asian, problem. Decision-makers around the world apparently believed that the disease could be contained and controlled within the region ...
Lukasz Gruszczynski
semanticscholar +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source