Results 111 to 120 of about 25,202 (233)

Tenascin knockout mice: barrels, boundary molecules, and glial scars

, 1995
In light of a previous report suggesting that the brains of tenascin- deficient animals are grossly normal, we have studied the somatosensory cortical barrel field and injured cerebral cortex in postnatal homozygous tenascin knockout, heterozygote, and ...
A Yoshiki, A Faissner, D Settles, M Kusakabe, HP Erickson, DA Steindler, ED Laywell   +6 more
core   +1 more source

Mapping the pro-inflammatory epitope of tenascin-C: How tenascin-C activates toll-like receptor 4 [PDF]

, 2016
Endogenous molecules, including extracellular matrix (ECM) proteins, have been shown to induce inflammation via toll-like receptor (TLR) activation in order to drive an immune response to tissue damage. Tenascin-C, an ECM glycoprotein transiently induced

core   +1 more source

Integrated Multi‐Omics Analysis of Human Cerebrospinal Fluid in Traumatic Spinal Cord Injury: An Exploratory Pilot Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Integrated proteomic and metabolomic profiling of human cerebrospinal fluid outlines a distinct molecular landscape of acute traumatic spinal cord injury. This exploratory analysis highlights a novel GOT2‐associated metabolic signature, involving concurrent decreases of GOT2, methionine, and 4‐acetamidobutanoic acid.
Wenkang Jiang, Yao Wang, Wei Miao, Huandong Liu, Qiujiang Qiao, Ting Jiang, Chenyan Shen, Zetian Zhou, Huilin Cheng, Ning Li   +9 more
wiley   +1 more source

Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro.

, 2010
The microenvironment hosting a tumor actively participates in regulating tumor cell proliferation, migration, and invasion. Among the extracellular matrix proteins enriched in the stroma of carcinomas are the tenascin family members tenascin-C and ...
Brellier, F., Degen, M., Enrico Martina, Martina, E., Chiquet-Ehrismann, R., Merlo, A., Martin Degen, Ruth Chiquet‐Ehrismann, Rüegg, C., Maddalena M. Lino, Adrian Merlo, Florence Brellier, Curzio Ruegg, Lino, M.M., Degen M, Lino MM, Brellier F, Merlo A, Martina E, Chiquet-Ehrismann R, Rüegg C   +20 more
core   +1 more source

The microbiome and brain metastasis in non‐small cell lung cancer: A graded appraisal and a framework for prevention‐oriented research

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This Review proposes a microbiome–premetastatic brain niche axis connecting gut, lung, and intratumoral microbes with metabolites, blood–brain barrier remodeling, neuroimmune priming, and brain metastasis in NSCLC. It integrates current evidence while distinguishing established mechanisms from associations and hypotheses requiring prospective and ...
Long Liang, Fangjuan Hu, Xiaofeng Wang, Chunhan Tang, Chun Wang, Gefei Jiang, Chungang Zhao, Yin Zhang, Churong Li   +8 more
wiley   +1 more source

Progenitor Timing Shapes NG2‐Glia Fate and Oligodendrocyte Differentiation

Glia, Volume 74, Issue 11, November 2026.
Developmental timing defines NG2‐glia and oligodendrocyte fate. E16 NG2‐progenitors produce large, more dispersed NG2‐glia clones. P0 progenitors show a bias toward oligodendrocyte differentiation. Temporal windows establish long‐term cortical glial heterogeneity.
Ana Cristina Ojalvo‐Sanz, Carolina Pernia‐Solanilla, Laura López‐Mascaraque   +2 more
wiley   +1 more source

Neointimal Hyperplasia and Restenosis: Epidemiology, Pathophysiology, Animal Models, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
The overall graphical diagram to summarize the pathological characteristics, pathogenesis, clinical manifestation, preclinical animal models, diagnostic methods, and intervention strategies for neointimal hyperplasia. Neointimal hyperplasia results from excessive proliferation and intimal migration of vascular smooth muscle cells (VSMCs) in the ...
Kaixu Wang, Daiyu Zhang, Yu Hu, Yixin Zhao, Xinling Wang, Long Jiang, Meixiu Jiang   +6 more
wiley   +1 more source

Tendinopathy: Types, Epidemiology, Molecular Mechanisms, and Future Precision‐Oriented Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
This review presents tendinopathy as a heterogeneous disorder driven by dynamic interactions among mechanical sensing, inflammation, angiogenesis and innervation, and extracellular matrix remodeling. Integrating clinical phenotypes with imaging, biomarkers, and multi‐omics may enable molecular subtyping and mechanism‐guided interventions, advancing ...
Yang Wu, Junyi Long, Meng Yang, Hongjie Huang, Jianquan Wang   +4 more
wiley   +1 more source

Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10428-10438, November 2026.
ABSTRACT Background Genetic clusters related to Type 2 diabetes (T2D) have differential impact on cardiovascular diseases (CVDs), although the underlying mechanisms, such as proteomic perturbation, remain unexplored. We conducted a network Mendelian randomisation (MR) study to identify proteomic mediators linking T2D genetic clusters and CVDs.
Shuang Liao, Gabriel Chun Yin Sung, Yiwen Liang, Chenxi Li, Shiu Lun Au Yeung   +4 more
wiley   +1 more source

Tenascin expression in hyperproliferative skin diseases

, 1991
The expression of tenascin, a recently discovered extracellular matrix glycoprotein, was studied by immunohistochemistry in normal human skin and in a number of skin diseases with epidermal hyperproliferation such as psoriasis, basal cell carcinoma ...
Oosterling, B, Van den Born, J, Mackie, E J, Perret, C, Schalkwijk, J, Van Vlijmen, I, Koopman, R   +6 more
core   +1 more source