Results 11 to 20 of about 25,202 (233)
Tenascin-W: Discovery, Evolution, and Future Prospects [PDF]
Frontiers in Immunology, 2021 Of the four tenascins found in bony fish and tetrapods, tenascin-W is the least understood. It was first discovered in the zebrafish and later in mouse, where it was mistakenly named tenascin-N.
Martin Degen +2 more
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BMC Ecology and EvolutionBackground The evolution of extracellular matrix is tightly linked to the evolution of organogenesis in metazoans. Tenascins are extracellular matrix glycoproteins of chordates that participate in integrin-signaling and morphogenetic events.
Josephine C. Adams, Richard P. Tucker
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Journal of Cell Science, 2016 ABSTRACT Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that it evolved before fibronectin.
Midwood, Kim +3 more
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The Adhesion Modulating Properties of Tenascin-W [PDF]
International Journal of Biological Sciences, 2012 Tenascins are extracellular matrix glycoproteins associated with cell motility, proliferation and differentiation. Tenascin-C inhibits cell spreading by binding to fibronectin; tenascin-R and tenascin-X also have anti-adhesive properties in vitro.
Florence Brellier, Enrico Martina, Matthias Chiquet, Jacqueline Ferralli, Michael van der Heyden, Gertraud Orend, Johannes C. Schittny, Ruth Chiquet-Ehrismann, Richard P. Tucker
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The last tenascin : insights on tenascin-W functions and regulation [PDF]
, 2012 Over the last decade, it became clear that the tumor stroma plays an active role in the process of tumor progression, by interacting with the transformed cells and providing a permissive microenvironment for malignant growth. The tumor microenvironment is a complex system comprised of extracellular matrix and the different cell populations within it ...
Martina, Enrico
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Phylogenetic analysis of the tenascin gene family: evidence of origin early in the chordate lineage [PDF]
BMC Evolutionary Biology, 2006 Background Tenascins are a family of glycoproteins found primarily in the extracellular matrix of embryos where they help to regulate cell proliferation, adhesion and migration.
Tucker RP +5 more
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The expression of tenascin‐C and tenascin‐W in human ossicles [PDF]
Journal of Anatomy, 2016 AbstractThe ossicles of the middle ear (the malleus, incus and stapes) transmit forces resulting from vibrations of the tympanic membrane to the cochlea where they are coded as sound. Hearing loss can result from diseases such as rheumatoid arthritis (RA) that affect the joints between the ossicles or degenerative processes like otosclerosis that lead ...
Tucker RP +4 more
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The Expression and Possible Functions of Tenascin-W During Development and Disease [PDF]
Frontiers in Cell and Developmental Biology, 2019 Tenascins are a family of multifunctional glycoproteins found in the extracellular matrix of chordates. Two of the tenascins, tenascin-C and tenascin-W, form hexabrachions.
Richard P. Tucker, Martin Degen
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The Synaptic Extracellular Matrix: Long-Lived, Stable, and Still Remarkably Dynamic
Frontiers in Synaptic Neuroscience, 2022 In the adult brain, synapses are tightly enwrapped by lattices of the extracellular matrix that consist of extremely long-lived molecules. These lattices are deemed to stabilize synapses, restrict the reorganization of their transmission machinery, and ...
Tal M. Dankovich +3 more
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Localization of tenascin in human skin wounds [PDF]
, 1993 A total of 56 surgically treated human skin wounds with a wound age between 8h and 7 months were investigated. Tenascin was visualized by immunohistochemistry and appeared first in the wound area pericellularly around fibroblastic cells approximately 2 ...
Penning, R. +4 more
core +1 more source