Results 21 to 30 of about 25,202 (233)
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Characterization of tenascin-C-induced signaling in tumorigenesis [PDF]
, 2008 During cancer progression, the extracellular matrix (ECM) is extensively remodeled. The ECM molecule tenascin-C is an adhesion-modulating molecule, which is highly expressed in tumor stroma.
Lange, Katrin
core +1 more source
Integrin Activation: Implications for Axon Regeneration
Cells, 2018 Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration.
Menghon Cheah, Melissa R. Andrews
doaj +1 more source
Tenascins : prominent molecules in tumor stroma [PDF]
, 2007 A very special connective tissue surrounds and interweaves solid tumors, the tumor stroma. Initially thought to only have a passive role, there is now more and more evidence accumulating that the tumor stroma plays an active function in the process of ...
Degen, Martin
core +1 more source
Characterization of tenascin-W, an emerging player in the metastatic bone marrow niche [PDF]
, 2015 Tumors are heterogeneous organ-like tissues including not only tumor cells themselves but also auxiliary cells such as, endothelial cells, fibroblasts, inflammatory cells, and bone marrow derived stem or stromal cells (BMSCs), which collectively create ...
Chiovaro, Francesca
core +1 more source
Advances in Laboratory Medicine, 2023 The chimeras causing the CAH-X syndrome (SCAH-X) result from recombination between CYP21A2-TNXB and their respective pseudogenes (CYP21A1P-TNXA). The clinical manifestations of this syndrome include congenital adrenal hyperplasia (CAH) and Ehlers–Danlos ...
Figueras Laura Martínez +4 more
doaj +1 more source
The evolution of tenascins and fibronectin [PDF]
Cell Adhesion & Migration, 2015 Tenascins are extracellular matrix glycoproteins that act both as integrin ligands and as modifiers of fibronectin-integrin interactions to regulate cell adhesion, migration, proliferation and differentiation. In tetrapods, both tenascins and fibronectin bind to integrins via RGD and LDV-type tripeptide motifs found in exposed loops in their ...
Adams, Josephine C +2 more
openaire +5 more sources
Transcriptional regulation of tenascin genes [PDF]
, 2015 Extracellular matrix proteins of the tenascin family resemble each other in their domain structure, and also share functions in modulating cell adhesion and cellular responses to growth factors.
Chiquet-Ehrismann, Ruth +5 more
core +2 more sources
Tenascin-C: a marker and driver of inflammation [PDF]
, 2020 Tenascin-C, the founding member of the matricellular tenascin family, is a large multifunctional hexameric extracellular matrix (ECM) glycoprotein. It is abundantly expressed in the developing embryo but its expression becomes tightly regulated in the ...
Ozanne, James Henry John
core +1 more source
Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression
EMBO Molecular Medicine, 2021 Immune checkpoint therapy, where CD8 tumor infiltrating T lymphocytes (TIL) are reactivated, is a promising anti‐cancer treatment approach, yet with low response rates. The extracellular matrix, in particular tenascin‐C, may generate barriers for TIL. To
Devadarssen Murdamoothoo +18 more
doaj +1 more source