Results 181 to 190 of about 19,761,198 (221)
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Tenascin-C, Tenascin-R and Tenascin-X: A Family of Talented Proteins in Search of Functions
Current Opinion in Cell Biology, 1993"Mice develop normally without tenascin", was a shock to biologists studying the extracellular matrix. Could tenascin be a useless protein? This seems most improbable, as it is conserved in every vertebrate species. Moreover, two new proteins have been discovered in the last year that are closely related to the original tenascin, providing evidence for
Harold P Erickson
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Tenascin-C Induced Signaling in Cancer
Cancer Letters, 2006Tenascin-C is an adhesion modulatory extracellular matrix molecule that is highly expressed in the microenvironment of most solid tumors. High tenascin-C expression reduces the prognosis of disease-free survival in patients with some cancers. The possible role of tenascin-C in tumor initiation and progression is addressed with emphasis on underlying ...
Gertraud Orend, Ruth Chiquet-Ehrismann
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Tenascin-C knockout mouse has no detectable tenascin-C protein
Journal of Neuroscience Research, 1997A recent study by Mitrovic and Schachner (J Neurosci Res 42:710-717, 1995) reported the detection of a small amount of truncated tensacin-C (TN-C) in the nervous system of the TN-C knockout mice created by Saga et al. (Genes Dev 6:1821-1831, 1992).
D L, Settles +4 more
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A virological view of tenascin-C in infection
American Journal of Physiology-Cell Physiology, 2023Tenascin-C is a large extracellular matrix glycoprotein with complex, not yet fully unveiled roles. Its context- and structure-dependent modus operandi renders tenascin-C a puzzling protein. Since its discovery ∼40 years ago, research into tenascin-C biology continues to reveal novel functions, the most recent of all being its immunomodulatory ...
Lorena Zuliani-Alvarez +1 more
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Detection of tenascin‐C in the nervous system of the tenascin‐C mutant mouse
Journal of Neuroscience Research, 1995AbstractWe have investigated the expression of tenascin‐C (TN‐C) in the somatosensory cortex of early postnatal mutant mice in which lacZ was reported to be expressed in place of tenascin (Saga et al.: Genes Dev 6:1821‐1831, 1992). At both the mRNA and protein levels, TN‐C was detected at levels lower in the mutant than in wild type animals by in situ ...
Mitrovic N, Schachner M
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Distinct Tissue Distribution in Pigs of Tenascin-X and Tenascin-C Transcripts [PDF]
FEBS Journal, 1995 Tenascin‐X and tenascin‐C glycoproteins are phylogenetically conserved components of the extracellular matrix, although their specific roles remain to be determined. cDNA probes were produced from pig tenascin‐X and tenascin‐C genes and were used to examine the tissue distribution of the transcripts in 28 tissues from Large‐White pigs, 4.5–42‐months ...
Geffrotin, Claudine +3 more
exaly +4 more sources
Tenascin-C in astrocytic tumors
Surgical Neurology, 2002Abstract The authors studied the expression of tenascin-C in 52 astrocytic tumor specimens and correlated it with proliferative indices. Tenascin-C immunoreactivity was found to be greater in tumor vessels and tumor networks of high-grade astrocytic tumors, and expression of TN-C in tumor vessels correlated with proliferative indices.
Giuseppe, Viale +3 more
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Immunolocalization of Tenascin-C in Vitiligo
Applied Immunohistochemistry & Molecular Morphology, 2012The disappearance of melanocytes because of defective adhesion is one of the accepted theories to explain vitiligo. Tenascin-C is a large, extracellular matrix glycoprotein that is thought to inhibit adhesion of melanocytes to fibronectin. The current study aimed to evaluate the pattern of tenascin-C expression in vitiligenous skin compared with normal
Asmaa Gaber, Abdou +3 more
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The Distribution of Tenascin-X Is Distinct and Often Reciprocal to That of Tenascin-C. [PDF]
Journal of Cell Biology, 1994 We have isolated a cDNA encoding mouse tenascin-X (TN-X), a new member of the family of tenascin genes. The TN-X gene lies in the major histocompatibility complex (MHC) class III region, as it is the case for its human counterpart. On Northern blots we detected a TN-X mRNA of approximately 13 kb in most tissues analyzed, whereas in various mouse cell ...
Teruyo Sakakura, R Chiquet-Ehrismann
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