Results 191 to 200 of about 19,761,198 (221)
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The tenascin-C knockout revisited
Journal of Cell Science, 1999ABSTRACT In the past seven years, two groups have independently produced tenascin-C-knockout mice. These mice are born alive and, originally, were described as showing no abnormalities. More recent studies, many involving pathological intervention, have shown that tenascin-C-knockout mice have several defects.
E J, Mackie, R P, Tucker
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The Role of Tenascin-C in Tissue Injury and Tumorigenesis [PDF]
Journal of Cell Communication and Signaling, 2009 The extracellular matrix molecule tenascin-C is highly expressed during embryonic development, tissue repair and in pathological situations such as chronic inflammation and cancer.
Kim S Midwood, Gertraud Orend
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Role of tenascin-C in articular cartilage
Modern Rheumatology, 2017Tenascin-C (TN-C) is a glycoprotein component of the extracellular matrix (ECM). TN-C consists of four distinct domains, including the tenascin assembly domain, epidermal growth factor-like repeats, fibronectin type III-like repeats, and the fibrinogen-like globe (FBG) domain. This review summarizes the role of TN-C in articular cartilage.
Masahiro, Hasegawa +2 more
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Tenascin-C in the cochlea of the developing mouse
The Journal of Comparative Neurology, 1999Tenascin-C is a glycoprotein of the extracellular matrix that acts in vitro as both a permissive and a nonpermissive substrate for neurite growth. We analyzed, by immunocytochemistry, the distribution of tenascin-C along neural growth pathways in the developing mouse cochlea.
D S, Whitlon, X, Zhang, M, Kusakabe
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Generation and characterization of dromedary Tenascin-C and Tenascin-W specific antibodies
Biochemical and Biophysical Research Communications, 2020Tenascin-C (TNC) and tenascin-W (TNW), large hexameric glycoproteins overexpressed in the tumor microenvironment, are useful tumor biomarkers for theranostic applications. For now, polyclonal and monoclonal antibodies, as well as aptamers targeting TNC and TNW have been developed.
Sayda Dhaouadi +11 more
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Analysis of structure and function of tenascin-C
The International Journal of Biochemistry & Cell Biology, 2006Tenascin-C is a multidomain large extracellular matrix glycoprotein composed of six monomers. The size of tenascin-C monomers (180-250 kDa) varies as a result of an alternative splicing of the fibronectin repeats at the pre-mRNA level. For the first time we applied bioinformatic and molecular modeling procedures, for detailed analysis of the ...
Jakub, Pas +6 more
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Tenascin-C in human cardiac pathology
Clinica Chimica Acta, 2012Tenascin-C (TN-C), a hexameric extracellular matrix glycoprotein, is a pleiotropic regulator of a variety of cell functions associated with embryogenesis, wound healing, cell proliferation, differentiation, motility, and nerve regeneration. Due to its role in remodeling processes, TN-C is involved with many pathologic states including cardiac and ...
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Experimental Neurology, 2000
The members of the tenascin family are involved in a number of developmental processes, mainly by their ability to regulate cell adhesion. We have here studied the distribution of mRNAs for tenascin-X, -C, and -R and the closely related molecule tenascin/J1 in the olfactory system and spinal cord. The olfactory bulb and nasal mucosa were studied during
M, Deckner +3 more
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The members of the tenascin family are involved in a number of developmental processes, mainly by their ability to regulate cell adhesion. We have here studied the distribution of mRNAs for tenascin-X, -C, and -R and the closely related molecule tenascin/J1 in the olfactory system and spinal cord. The olfactory bulb and nasal mucosa were studied during
M, Deckner +3 more
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Cell Adhesion and Communication, 1996
Tenascin-C is an extracellular matrix glycoprotein with trophic and repulsive properties, involved in migratory processes in CNS. Previous reports demonstrated that this molecule is produced and secreted by astrocytes. Preliminary data on fibroblasts and astrocytes have suggested that bFGF may modulate tenascin-C expression.
M, Mahler +4 more
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Tenascin-C is an extracellular matrix glycoprotein with trophic and repulsive properties, involved in migratory processes in CNS. Previous reports demonstrated that this molecule is produced and secreted by astrocytes. Preliminary data on fibroblasts and astrocytes have suggested that bFGF may modulate tenascin-C expression.
M, Mahler +4 more
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Annals of Anatomy - Anatomischer Anzeiger, 2004
Different distributions of tenascin-C and -X are found in various organs. However, the role of the tenascin family in the process of formation in the papillae epithelium during development is poorly understood. In order to find more information an tenascin-C and -X distributions during tongue development, immunohistocheminical studies have been carried
Kazuhiro, Watanabe +2 more
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Different distributions of tenascin-C and -X are found in various organs. However, the role of the tenascin family in the process of formation in the papillae epithelium during development is poorly understood. In order to find more information an tenascin-C and -X distributions during tongue development, immunohistocheminical studies have been carried
Kazuhiro, Watanabe +2 more
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