Results 41 to 50 of about 19,761,198 (221)
Generation of a tenascin-C-CreER2 knockin mouse line for conditional DNA recombination in renal medullary interstitial cells. [PDF]
PLoS ONE, 2013 Renal medullary interstitial cells (RMIC) are specialized fibroblast-like cells that exert important functions in maintaining body fluid homeostasis and systemic blood pressure.
Wenjuan He +8 more
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Advances on the roles of tenascin-C in cancer
Journal of Cell Science, 2022 ABSTRACT The roles of the extracellular matrix molecule tenascin-C (TNC) in health and disease have been extensively reviewed since its discovery over 40 years ago. Here, we will describe recent insights into the roles of TNC in tumorigenesis, angiogenesis, immunity and metastasis.
Alev Yilmaz +9 more
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Revisiting the Tenascins: Exploitable as Cancer Targets?
Frontiers in Oncology, 2022 For their full manifestation, tumors require support from the surrounding tumor microenvironment (TME), which includes a specific extracellular matrix (ECM), vasculature, and a variety of non-malignant host cells.
Richard P. Tucker, Martin Degen
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Transcriptional regulation of tenascin genes [PDF]
, 2015 Extracellular matrix proteins of the tenascin family resemble each other in their domain structure, and also share functions in modulating cell adhesion and cellular responses to growth factors.
Chiquet-Ehrismann, Ruth +5 more
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Immunosuppression via Tenascin-C
Oncoscience, 2015 Metastasis accounts for most of the prostate cancer-related deaths, and the presence of more than two metastatic lymph nodes at radical prostatectomy and extended pelvic lymph node (PLN) dissection is an independent predictor of prostate cancer specific mortality [1], thus suggesting that PLN invasion is an important event in the history of the disease.
Matteo, Bellone +2 more
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Animal Cells and Systems, 2020 Previously, we reported that endometrial stromal (ES) and endometrial epithelial (EE) cells did not attach to tenascin C, indicating the absence of active integrin α9β1 on the surface of mouse ES and EE cells.
Hye Jin Park, Jung Im Yun, Seung Tae Lee
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Journal of Inflammation Research, 2021 Rui Peng, Yan Li Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, People’s Republic of ChinaCorrespondence: Yan LiDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University, 238 ...
Peng R, Li Y
doaj
Tenascin-C: Friend or Foe in Lung Aging?
Frontiers in Physiology, 2021 Lung aging is characterized by lung function impairment, ECM remodeling and airspace enlargement. Tenascin-C (TNC) is a large extracellular matrix (ECM) protein with paracrine and autocrine regulatory functions on cell migration, proliferation and ...
Sandrine Gremlich +7 more
doaj +1 more source
YAP/TAZ regulates the expression of proteoglycan 4 and tenascin C in superficial-zone chondrocytes [PDF]
European Cells & Materials, 2020 The roles of cell division control protein 42 homologue (CDC42) and actin polymerisation in regulating the phenotype of superficial-zone chondrocytes (SZCs) have been demonstrated in vitro; however, the signalling pathway(s) downstream have yet to be ...
E Delve +5 more
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The role of tenascin C in cardiovascular disease [PDF]
Cardiovascular Research, 2011 The extracellular matrix protein tenascin C (TnC) is expressed in a variety of embryonic tissues, but its expression in adult arteries is co-incident with sites of vascular disease. TnC expression has been linked to the development and complications of intimal hyperplasia, pulmonary artery hypertension, atherosclerosis, myocardial infarction, and heart
Golledge, J. +4 more
openaire +3 more sources