Results 201 to 210 of about 28,869 (265)

Bictegravir/emtricitabine/tenofovir alafenamide in clinical practice for people with HIV: final 24-month effectiveness and safety outcomes in key populations in the observational BICSTaR cohort

HIV Research & Clinical Practice
Background: BICtegravir Single Tablet Regimen (BICSTaR) is an observational cohort study evaluating the effectiveness and safety of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in treatment-naïve (TN) and treatment-experienced (TE) people ...
Benoit Trottier, Chia-Jui Yang, Dai Watanabe, G. Marchetti, Daniel Elbirt, E. de Barra, Alper Gündüz, Sun Hee Lee, R. Vogelmann, O. Robineau, C. Choy, M. Berrevoets, A. Uriel, D. Thorpe, Marion Heinzkill, A. Marongiu, Johanna Ramroth, Lisa D'Amato, Josep Mallolas   +18 more
semanticscholar   +1 more source

Maintenance therapy with dolutegravir and lamivudine versus bictegravir, emtricitabine, and tenofovir alafenamide in people with HIV (PASO-DOBLE): 48-week results from a randomised, multicentre, open-label, non-inferiority trial.

The Lancet HIV
BACKGROUND Although single-tablet, oral bictegravir, emtricitabine, and tenofovir alafenamide or dolutegravir and lamivudine are preferred regimens in several major guidelines and are widely used in many countries, they have not been compared in a fully ...
P. Ryan, J. L. Blanco, Mar Masiá, L. García-Fraile, M. Crusells, Pere Domingo, Adrià Curran, Roberto Guerri-Fernandez, E. Bernal, J. Bravo, B. Revollo, J. Macías, J. Tiraboschi, R. Montejano, C. Amador, Miguel Torralba, D. Merino, V. Díaz-Brito, M. J. Galindo, Sergio Ferra, Aroa Villoslada, J. Losa, F. Fanjul, Xavier Perez-Stachowski, Joaquim Peraire, Joaquín Portilla, S. de la Fuente, Carlos Dueñas, M. Vázquez, Silvana Di Gregorio, H. Esteban, Pedro Gil, M. de Miguel, B. Alejos, Esteban Martínez   +34 more
semanticscholar   +1 more source

Doravirine/Islatravir (100/0.75 mg) Once-Daily Compared With Bictegravir/Emtricitabine/Tenofovir Alafenamide as Initial HIV-1 Treatment: 48-Week Results From a Phase 3, Randomized, Controlled, Double-Blind, Noninferiority Trial

Clinical Infectious Diseases
Background Doravirine/islatravir is an investigational regimen that is being studied for human immunodeficiency virus type 1 (HIV-1) treatment. Methods In this phase 3, double-blind, double-dummy trial (ClinicalTrials.gov NCT04233879), previously ...
J. Rockstroh, R. Paredes, P. Cahn, Jean-Michel Molina, Simiso M Sokhela, F. Hinestrosa, S. Kassim, Douglas Cunningham, J. Ghosn, J. Bogner, H. Gatanaga, Ernest Asante-Appiah, Ying Zhang, Uchechukwu Nwoke, Stephanie O Klopfer, Karen Eves, Kathleen Squires, Todd Correll, Michelle C Fox, M. Pisculli   +19 more
semanticscholar   +1 more source

Impact of Tenofovir Alafenamide on Lipid Profiles in Chronic Hepatitis B Patients: Systematic Review and Meta‐Analysis

Journal of Medical Virology
Tenofovir alafenamide (TAF) is widely used for chronic hepatitis B (CHB) treatment due to its improved renal and bone safety compared to tenofovir disoproxil fumarate (TDF).
Ping-Yu Hsu, Hui-Chen Su, Mi-Chia Ma, Chien-An Chen, Sin-Yi Yu, Yi-Ming Hua   +5 more
semanticscholar   +1 more source

Efficacy and Safety of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil Fumarate (TDF) Followed by TAF in Chronic Hepatitis B Patients of East Asian Ethnicity Following 5 Years of Treatment

Alimentary Pharmacology and Therapeutics
Tenofovir alafenamide (TAF) has shown non‐inferior efficacy to tenofovir disoproxil fumarate (TDF), with superior bone and renal safety.
G. Wong, Edward Gane, Calvin Q. Pan, Scott Fung, Mang M Ma, Namiki Izumi, Shalimar, Seng Gee Lim, Wan-Long Chuang, R. Mehta, Young-Suk Lim, Leland J. Yee, John F Flaherty, F. Abramov, Hongyuan Wang, M. Buti   +15 more
semanticscholar   +1 more source

Tenofovir alafenamide promotes weight gain and impairs fatty acid metabolism-related signaling pathways in visceral fat tissue compared to tenofovir disoproxil fumarate.

Antiviral Research
Modern antiretroviral therapy (ART) is associated with rapid weight gain, which appears to be antiretroviral-specific. Tenofovir is a nucleoside reverse transcriptase inhibitor commonly employed as a backbone in many ART formulations.
Bryan Dulion, Arnold Olali, Niyati Patel, Amber K. Virdi, A. Naqib, Jennillee Wallace, Ryan D. Ross   +6 more
semanticscholar   +1 more source

Incidences of Virological and Clinical Relapses After Cessation of Tenofovir Alafenamide, Tenofovir Disoproxil Fumarate, or Entecavir in Patients With HBeAg‐Negative Chronic Hepatitis B

Journal of Gastroenterology and Hepatology
The relapse pattern following the discontinuation of tenofovir alafenamide (TAF) in patients with chronic hepatitis B (CHB) remains unclear. This study aimed to compare the 2‐year incidences of virological and clinical relapses among patients who ...
Cheng-Hao Tseng, Teng-Yu Lee, Chi-Yi Chen, Chung‐Feng Huang, Po-Yueh Chen, Tyng-Yuang Jang, Tzeng‐Huey Yang, Chiao-Ching Wu, Yao-Chun Hsu   +8 more
semanticscholar   +1 more source

Bictegravir/emtricitabine/tenofovir alafenamide after virologic failure to cabotegravir/rilpivirine

AIDS (London)
Bictegravir/emtricitabine/tenofovir alafenamide after virologic ...
Pierre Giguère, Kyla Agtarap, Michaeline McGuinty, C. Touchie, Steve Kravcik, Jonathan B. Angel   +5 more
semanticscholar   +1 more source

Weight gain on tenofovir alafenamide fumarate‐based therapy compared to tenofovir disoproxil fumarate‐ and abacavir‐based therapy in children and young people living with HIV in Europe

HIV Medicine
To compare BMI‐for‐age z‐score (zBMI) changes in treatment‐experienced children and young people living with HIV aged 6 to
Siobhan Hannah Katja Luminita Luisa Tessa Sannie Brit Chri Crichton Castro Doerholt Ene Galli Goetghebuer Nor, S. Crichton, Hannah Castro, Katja Doerholt, L. Ene, Luisa Galli, T. Goetghebuer, S. Nordly, Christoph Königs, Magda Marczynska, Andrea Marongiu, Lars Navér, Marisa Navarro, Antoni Noguera-Julián, P. Paioni, V. Spoulou, V. Vieira, C. Jackson, I. Collins, Ali Judd, E. Chappell, L. Miguel, Borja Guarch-Ibáñez, John O’Rourke, Katia Prime, Beatriz Ruiz-Saez, Sandra Soeria-Atmadja, A. Turkova   +27 more
semanticscholar   +1 more source

Tenofovir Alafenamide Therapy Throughout Pregnancy in Mothers With Hepatitis B

Alimentary Pharmacology and Therapeutics
Mothers with chronic hepatitis B and advanced fibrosis may require antiviral therapy throughout pregnancy. Current guidelines recommend tenofovir disoproxil fumarate (TDF), which is unsuitable for mothers at risk of renal dysfunction or decreased bone ...
Xingfei Pan, Liyang Zhou, Jing Hu, Panpan Zhai, X. Ou, Fang He, Calvin Q. Pan   +6 more
semanticscholar   +1 more source