Results 101 to 110 of about 3,568,014 (331)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Bouncing Negative-Tension Branes
, 2008 Braneworlds, understood here as double domain wall spacetimes, can be described in terms of a linear harmonic function, with kinks at the locations of the boundary branes.
Jean-Luc Lehners +2 more
core +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
Nature, 2010 Mechanical forces are central to developmental, physiological and pathological processes. However, limited understanding of force transmission within sub-cellular structures is a major obstacle to unravelling molecular mechanisms.
C. Grashoff +10 more
semanticscholar +1 more source
Does $$\varLambda $$CDM really be in tension with the Hubble diagram data? [PDF]
, 2020 Ahmad Mehrabi, Spyros Basilakos
openalex +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Polish Maritime Research, 2016 This paper presents a metod for reliability assessment of structural components on the basis of diagnostic parameters recorded during operation of aircraft and sea going ships.
Tomaszek Henryk +2 more
doaj +1 more source
Friedmann branes with variable tension
, 2008 We introduce brane-worlds with non-constant tension, strenghtening the analogy with fluid membranes, which exhibit a temperature-dependence according to the empirical law established by E\"otv\"os.
C. Lanczos +7 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source