Results 121 to 130 of about 3,568,014 (331)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Tensions in Learner Support and Tutor Support in Tertiary Web-based English Language Education in China

International Review of Research in Open and Distributed Learning, 2005
Based on the findings of a national survey conducted in 2004 designed to examine the support systems for both learners and tutors engaged in tertiary-level Web-based English education in mainland China, this paper reports the findings of secondary ...
Tong Wang
doaj  

Tensions on the actin cytoskeleton and apical cell junctions in the C. elegans spermatheca are influenced by spermathecal anatomy, ovulation state and activation of myosin

Frontiers in Cell and Developmental Biology
IntroductionCells generate mechanical forces mainly through myosin motor activity on the actin cytoskeleton. In C. elegans, actomyosin stress fibers drive contractility of the smooth muscle-like cells of the spermatheca, a distensible, tube-shaped tissue
Fereshteh Sadeghian, Noa W. F. Grooms, Samuel H. Chung, Erin J. Cram   +3 more
doaj   +1 more source

Cosmology Intertwined II: The Hubble Constant Tension [PDF]

, 2020
E. D. Valentino, L. Anchordoqui, Ozgur Akarsu, Y. Ali-Haimoud, Luca Amendola, N. Arendse, M. Asgari, M. Ballardini, S. Basilakos, E. Battistelli, M. Benetti, S. Birrer, F. Bouchet, M. Bruni, E. Calabrese, D. Camarena, S. Capozziello, Angela Chen, J. Chluba, A. Chudaykin, Eoin 'O Colg'ain, F. Cyr-Racine, P. Bernardis, J. P'erez, J. Delabrouille, J. Dunkley, C. Escamilla-Rivera, A. Fert'e, F. Finelli, Wendy L. Freedman, N. Frusciante, E. Giusarma, Adria G'omez-Valent, Julien Guy, W. Handley, Ian Harrison, Luke Hart, Alan Heavens, Hendrik Hildebrandt, Daniel E. Holz, D. Huterer, Mikhail M. Ivanov, S. Joudaki, M. Kamionkowski, Tanvi Karwal, L. Knox, Suresh Kumar, L. Lamagna, J. Lesgourgues, Matteo Lucca, V. Marra, S. Masi, S. Matarrese, Arindam Mazumdar, A. Melchiorri, Olga Mena, L. Mersini-Houghton, V. Miranda, Cristian Moreno-Pulido, David F. Mota, J. Muir, A. Mukherjee, Florian Niedermann, A. Notari, Rafael C. Nunes, F. Pace, A. Paliathanasis, A. Palmese, S. Pan, D. Paoletti, V. Pettorino, F. Piacentini, V. Poulin, M. Raveri, A. Riess, V. Salzano, E. Saridakis, A. A. Sen, A. Shafieloo, A. Shajib, J. Silk, A. Silvestri, M. Sloth, Tristan L. Smith, Joan Solà, C. V. D. Bruck, L. Verde, L. Visinelli, B. Wandelt, Deng Wang, Jian-Min Wang, A. K. Yadav, Weiqiang Yang   +92 more
semanticscholar   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Younger-Brother Motif in Genesis as an Object of Love and Hatred in the Family: Tensions, Conflicts and Reflection for the Contemporary African Family

Old Testament Essays, 2017
The younger-brother motif in the book of Genesis reflects tension and conflict in a family. The younger brother in some cases becomes an object of hatred to his siblings but is loved by the parent and this has devastating consequences for the family ...
Emmanuel Kojo Ennin Antwi
doaj   +1 more source

Design of wirerope tension monitoring system of mine hoist

Gong-kuang zidonghua, 2014
In view of problems of overload and unbalanced tension of wirerope existed in mine hoist, a wirerope tension monitoring system of mine hoist was designed.
SHI Tongjun, WANG Peng, WANG Bo
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Prediction of tensile power law creep constants from compression and bend data for ZrB2–20 vol% SiC composites at 1800 °C

Journal of Advanced Ceramics, 2017
Here we consider our four-point flexure and compression creep results obtained under Ar protection at 1800 °C to predict the tensile creep behavior of a ZrB2–20 vol% SiC ultra-high temperature ceramic.
Ali Khadimallah, Marc W. Bird, Kenneth W. White   +2 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source