Results 71 to 80 of about 64,643 (259)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Role of Tension Band Wiring as a Preliminary Step in Reduction and Fixation of Fracture Mandible [PDF]

Zagazig University Medical Journal
Background: There have been numerous studies on different techniques for fixation-based reduction of mandible fractures. Tension band wiring could be one of the internal fixation methods with good management results.
Alaa El Sadek, Ahmed Aly, Khaled Elkatcha   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Comparing the Knotless Tension Band and the Traditional Stainless Steel Wire Tension Band Fixation for Medial Malleolus Fractures: A Retrospective Clinical Study

Scientifica, 2016
The traditional stainless steel wire tension band (WTB) has been popularized for small avulsion fractures at the medial malleolus. Despite the tension band principle creating a stable construct, complications continue to arise utilizing the traditional ...
Michael W. Downey, Kyle Duncan, Victor Kosmopoulos, Travis A. Motley, Brian B. Carpenter, Fadeke Ogunyankin, Alan Garrett   +6 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Modeling cell elongation during germ band retraction: cell autonomy versus applied anisotropic stress

New Journal of Physics, 2014
The morphogenetic process of germ band retraction in Drosophila embryos involves coordinated movements of two epithelial tissues—germ band and amnioserosa.
Holley E Lynch, Jim Veldhuis, G Wayne Brodland, M Shane Hutson   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

การประเมินคุณภาพและความพึงพอใจต่อหุ่นจำลองกระดูกสะบ้าแตกสำหรับการฝึกหัตถการ Tension Band Wiring

Siriraj Medical Bulletin
วัตถุประสงค์:เพื่อประเมินคุณภาพและความพึงพอใจต่อหุ่นจำลองกระดูกสะบ้าแตกสำหรับใช้ในการเรียนการสอนหัตถการ Tension band wiring วิธีการศึกษา: การศึกษานี้จัดทำขึ้น ณ โรงพยาบาลศิริราช เป็นการศึกษาแบบภาคตัดขวางโดยใช้แบบสอบถามการประเมินคุณภาพและความพึงพอใจต่อหุ่นจำลองกระดูกสะบ้าแตก กลุ่มตัวอย่างทั้งสิ้น 36 คน เป็นแพทย์ผู้เชี่ยวชาญสาขาออร์โธปิดิกส์ ที่ม ...
openaire   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Olecranon fractures in children and adolescents: Outcomes based on fracture fixation

Journal of Children's Orthopaedics, 2018
Purpose Open reduction and internal fixation with a tension band construct is the standard treatment for displaced transverse intra-articular olecranon fractures. The purpose of this study is to describe the outcomes of tension band fixation of olecranon
C. A. Perkins, M. T. Busch, M. A. Christino, J. Axelrod, D. P. Devito, J. A. Fabregas, J. C. Flanagan, J. Murphy, D. Olszewski, M. L. Schmitz, T. Schrader, S. C. Willimon   +11 more
doaj   +1 more source