Results 101 to 110 of about 240 (114)

Tenuigenin exhibits anti-inflammatory activity via inhibiting MAPK and NF-κB and inducing Nrf2/HO-1 signaling in macrophages

Food & Function, 2016
Tenuigenin (TNG), isolated from the root of the Chinese herb Polygala tenuifolia , possesses various biological and pharmacological activities, including anti-oxidation and anti-inflammation activities.
Hongming, Lv, Wenzhi, Ren, Yuwei, Zheng, Lidong, Wang, Gejin, Lu, Pengfei, Yi, Xinxin, Ci   +6 more
openaire   +2 more sources

Tenuigenin Prevents IL-1β-induced Inflammation in Human Osteoarthritis Chondrocytes by Suppressing PI3K/AKT/NF-κB Signaling Pathway

Inflammation, 2016
Tenuigenin (TEN), the main active component of Polygala tenuifolia, has been reported to have anti-inflammatory effects. However, the effects of TEN on IL-1β-stimulated osteoarthritis chondrocytes have not been reported. The purpose of this study was to investigate the anti-inflammatory effects and mechanism of TEN on IL-1β-stimulated human ...
Chunlei, Wang, Lihong, Zeng, Tao, Zhang, Jiakun, Liu, Wenbo, Wang   +4 more
openaire   +2 more sources

Tenuigenin ameliorates Alzheimer’s disease by targeting MAP2K1: integrated evidence from network pharmacology and experimental validation

NeuroReport
Objective Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder primarily characterized by progressive cognitive impairment and synaptic dysfunction. Despite substantial research efforts, effective therapeutic options remain limited.
Chunyu, Fu, Yuna, Kan, Kedong, Guo, Liyan, Jiang, Yingbo, Zhang, Haiying, Dong, Jiaming, Xie   +6 more
openaire   +2 more sources

Tenuigenin ameliorates cognitive dysfunction in Alzheimer’s disease via hippocampal neurogenesis enhancement

Phytochemistry Letters, 2022
Kaili Lin, Zhu Zhang, Zhang Zhang, Wenjun Ding, Peili Zhu, Ying Wang, Xiaoli Jiang, Bin Liu, Ken Kin-Lam Yung, Shiqing Zhang   +9 more
openaire   +1 more source

Hydroxysafflor Yellow A and Tenuigenin Exhibit Neuroprotection Effects Against Focal Cerebral Ischemia Via Differential Regulation of JAK2/STAT3 and SOCS3 Signaling Interaction

Molecular Neurobiology
Numerous natural bioactive compounds extracted from Chinese medicines have been proved to be promising and potent agents in the treatment of ischemic stroke. Hydroxysafflor yellow A (HSYA), separated from Carthamus tinctorius, has increasingly attracted attention for its broad spectrum of pharmacological effects, especially of its neuroprotective ...
Lu Yu, Cheng Zhang, Lingling Gu, Hong Chen, Yan Huo, Shuyan Wang, Jie Tao, Chuan Xu, Qiujuan Zhang, Mingliang Ma, Jun Zhang   +10 more
openaire   +2 more sources

[The mechanism of tenuigenin for eliminating waste product accumulation in cerebral neurons of Alzheimer's disease rats via ubiquitin-proteasome pathway].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2015
To explore the scavenging action of tenuigenin (TEN) on intracerebral amyloid β protein (Aβ) aggregation and the abnormal phosphorylated tau protein and its mechanism in Alzheimer's disease (AD) rats' brain.Aβ1-40 was injected into the right CA1 region hippocampus to establish the AD model.
Qin, Chen, Yi-Qing, Chen, Hai-Yan, Ye, Jain-Qi, Yu, Qi-Quan, Shi, Yan, Huang   +5 more
openaire   +1 more source

[Protective effect of tenuigenin on cytotoxicity of primary cultures of cortical neurons induced by amyloid beta-protein 1-40 (Abeta(1-40))].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009
To observe the effect of tenuigenin (TEN) on aggregated amyloid beta-protein 1-40 (Abeta(1-40)-induced cytotoxicity of primary cultural cortical neurons in vitro.In order to establish neurotoxic model, the primary cultural rat cortical neurons were treated with 25 micromol x L(-1) aggregated Abeta(1-40), which were divided into a model group and 3 ...
Qin, Chen, Lei-ke, Li
openaire   +1 more source

Tenuigenin attenuates cerebral ischemia-reperfusion injury by regulating microglial polarization through  EGLN3/HIF-1α/NF-κB signaling pathway

Ethnopharmacological relevance: The role of herbal medicines in the treatment of stroke is receiving increasing attention. Polygala tenuifolia Willd, as a traditional Chinese herb, has been used in clinical practice for a long time to treat stroke and its related sequelae. It has a long history of application.
Mengjia Zhou, Wenting Xu, Jiaqing Liu, Lili Cui, Chaohui Wang, Rong Chen, Xiao Zhang, Renhao Xu, Lina Wang, Xiangjian Zhang, Lina Wang   +10 more
openaire   +1 more source

Tenuigenin Promotes Proliferation and Differentiation of Hippocampal Neural Stem Cells

Neurochemical Research, 2012
Xiaobo Huang, Ningqun Wang, Yujing Chen
exaly  

Tenuifolin, an Extract Derived From Tenuigenin, Inhibits Amyloid-β Secretion in Vitro

Acta Physiologica, 2009
Jun Lv, P Tu, K Beyreuther
exaly