Results 101 to 110 of about 234 (110)
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Inflammation, 2016
Tenuigenin (TEN), the main active component of Polygala tenuifolia, has been reported to have anti-inflammatory effects. However, the effects of TEN on IL-1β-stimulated osteoarthritis chondrocytes have not been reported. The purpose of this study was to investigate the anti-inflammatory effects and mechanism of TEN on IL-1β-stimulated human ...
Chunlei, Wang +4 more
openaire +2 more sources
Tenuigenin (TEN), the main active component of Polygala tenuifolia, has been reported to have anti-inflammatory effects. However, the effects of TEN on IL-1β-stimulated osteoarthritis chondrocytes have not been reported. The purpose of this study was to investigate the anti-inflammatory effects and mechanism of TEN on IL-1β-stimulated human ...
Chunlei, Wang +4 more
openaire +2 more sources
NeuroReport
Objective Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder primarily characterized by progressive cognitive impairment and synaptic dysfunction. Despite substantial research efforts, effective therapeutic options remain limited.
Chunyu, Fu +6 more
openaire +2 more sources
Objective Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder primarily characterized by progressive cognitive impairment and synaptic dysfunction. Despite substantial research efforts, effective therapeutic options remain limited.
Chunyu, Fu +6 more
openaire +2 more sources
Molecular Neurobiology
Numerous natural bioactive compounds extracted from Chinese medicines have been proved to be promising and potent agents in the treatment of ischemic stroke. Hydroxysafflor yellow A (HSYA), separated from Carthamus tinctorius, has increasingly attracted attention for its broad spectrum of pharmacological effects, especially of its neuroprotective ...
Lu Yu +10 more
openaire +2 more sources
Numerous natural bioactive compounds extracted from Chinese medicines have been proved to be promising and potent agents in the treatment of ischemic stroke. Hydroxysafflor yellow A (HSYA), separated from Carthamus tinctorius, has increasingly attracted attention for its broad spectrum of pharmacological effects, especially of its neuroprotective ...
Lu Yu +10 more
openaire +2 more sources
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2015
To explore the scavenging action of tenuigenin (TEN) on intracerebral amyloid β protein (Aβ) aggregation and the abnormal phosphorylated tau protein and its mechanism in Alzheimer's disease (AD) rats' brain.Aβ1-40 was injected into the right CA1 region hippocampus to establish the AD model.
Qin, Chen +5 more
openaire +1 more source
To explore the scavenging action of tenuigenin (TEN) on intracerebral amyloid β protein (Aβ) aggregation and the abnormal phosphorylated tau protein and its mechanism in Alzheimer's disease (AD) rats' brain.Aβ1-40 was injected into the right CA1 region hippocampus to establish the AD model.
Qin, Chen +5 more
openaire +1 more source
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009
To observe the effect of tenuigenin (TEN) on aggregated amyloid beta-protein 1-40 (Abeta(1-40)-induced cytotoxicity of primary cultural cortical neurons in vitro.In order to establish neurotoxic model, the primary cultural rat cortical neurons were treated with 25 micromol x L(-1) aggregated Abeta(1-40), which were divided into a model group and 3 ...
Qin, Chen, Lei-ke, Li
openaire +1 more source
To observe the effect of tenuigenin (TEN) on aggregated amyloid beta-protein 1-40 (Abeta(1-40)-induced cytotoxicity of primary cultural cortical neurons in vitro.In order to establish neurotoxic model, the primary cultural rat cortical neurons were treated with 25 micromol x L(-1) aggregated Abeta(1-40), which were divided into a model group and 3 ...
Qin, Chen, Lei-ke, Li
openaire +1 more source
Tenuifolin, an extract derived from tenuigenin, inhibits amyloid‐β secretion in vitro
Acta Physiologica, 2009Jun Lv, P Tu
exaly
Tenuigenin Attenuates α‐Synuclein‐Induced Cytotoxicity by Down‐Regulating Polo‐Like Kinase 3
CNS Neuroscience and Therapeutics, 2013Yue Huang +2 more
exaly