Results 81 to 90 of about 234 (110)

Tenuigenin down-regulates the release of nitric oxide, matrix metalloproteinase-9 and cytokines from lipopolysaccharide-stimulated microglia

Neuroscience Letters, 2017
Tenuigenin (TEN), an active component of Polygala tenuifolia root extracts, has been shown to provide neuroprotection in neurodegenerative disorders. To date, most of these studies have focused on the effect that TEN has on neurons. Because activated microglia can release neurotoxic factors that cause neuronal damage, the present study was designed to ...
Pingxiang Xu, Yan Zheng, Xiaomin Wang
exaly   +4 more sources

Tenuigenin inhibits LPS-induced inflammatory responses in microglia via activating the Nrf2-mediated HO-1 signaling pathway

European Journal of Pharmacology, 2017
Tenuigenin (TGN), a major active component of polygala tenuifolia root, has been reported to have anti-inflammatory effect. In this study, we investigated the anti-neuroinflammatory effects of TGN on LPS-induced inflammation both in vitro and in vivo.
Yuze Cao, Huixue Zhang, Qian Li
exaly   +4 more sources

Efficacy of tenuigenin and β-asarone as augmentations for memantine in the treatment of Alzheimer’s disease

NeuroReport, 2018
Alzheimer's disease (AD) is a progressive neurodegenerative disease that has no cure at present. This study was carried out to evaluate whether the combination of β-asarone and tenuigenin could improve the efficacy of memantine as a monotherapy in the treatment of AD. Patients with AD were recruited and assigned to two groups.
Haiying, Dong, Shuqin, Wu, Nan, Hu, Guihua, Xing   +3 more
openaire   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

Tenuigenin Promotes Proliferation and Differentiation of Hippocampal Neural Stem Cells

Neurochemical Research, 2011
The present study was to investigate the influence of tenuigenin, an active ingredient of Polygala tenuifolia Willd, on the proliferation and differentiation of hippocampal neural stem cells in vitro. Tenuigenin was added to a neurosphere culture and neurosphere growth was measured using MTT assay.
Huang Xiaobo
exaly   +3 more sources

Tenuigenin ameliorates learning and memory impairments induced by ovariectomy

Physiology and Behavior, 2013
Estrogen deficiency is associated with cognitive impairment. Hormone replacement therapy (HRT) has proven to be effective in preventing and reversing the memory and learning deficiencies. However, conventional estrogenic treatment could increase the risks of breast cancer and venous thromboembolism. Tenuigenin (TEN) is putatively believed as the active
Zhao-Lin Cai, Wen-Xiao Liu, Chu-Hua Li   +2 more
exaly   +3 more sources

Tenuigenin ameliorates acute lung injury by inhibiting NF-κB and MAPK signalling pathways

Respiratory Physiology and Neurobiology, 2015
We aimed to explore the protective effect of tenuigenin (TNG) on lipopolysaccharide (LPS)-stimulated inflammatory responses in acute lung injury (ALI). Thus, we assessed the effects of TNG on the LPS-induced production of tumour necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β in the culture supernatants of RAW 264.7 cells.
Hongming Lv, Chao Zhu, Yawen Gao
exaly   +3 more sources

Tenuigenin treatment improves behavioral Y-maze learning by enhancing synaptic plasticity in mice

Behavioural Brain Research, 2013
Polygala tenuifolia root has been used to improve memory and cognitive function in Traditional Chinese Medicine for more than 2000 years. Since tenuigenin (TEN) is one of the most utilized P. tenuifolia root extracts, it is surprising there is no evidence for the effects of TEN on learning and memory so far.
Jun-Ni Huang, Xiu-Li Wang, Wen-Xiao Liu   +2 more
exaly   +3 more sources

Tenuigenin enhances hippocampal Schaffer collateral-CA1 synaptic transmission through modulating intracellular calcium

Phytomedicine, 2015
Tenuigenin (TEN), a natural product from the Chinese herb Polygala tenuifolia root, has been reported to improve cognitive function and exhibits neuroprotective effects in pharmacological studies of the central nervous system. Synaptic transmission is the essential process of brain physiological functions such as learning and memory formation, and TEN ...
Li-Hua Yao, Jun-Ni Huang, Wen-Xiao Liu   +2 more
exaly   +3 more sources

Tenuigenin inhibits RANKL-induced osteoclastogenesis by down-regulating NF-κB activation and suppresses bone loss in vivo

Biochemical and Biophysical Research Communications, 2015
Tenuigenin, a major active component of polygala tenuifolia root, has been used to treat patients with insomnia, dementia, and neurosis. In this study, we aimed to investigate the effects of tenuigenin on osteoclastogenesis and clarify the possible mechanism.
Xianan Li, Liang Cheng, Hongwei Wu
exaly   +3 more sources

TMT-based quantitative proteomics reveals the protective mechanism of tenuigenin after experimental intracerebral hemorrhage in mice

Journal of Ethnopharmacology
Tenuigenin (TNG) is an extract obtained from Polygalae Radix. It possesses anti-inflammatory, antioxidant, and neuroprotective properties. However, the potential mechanism of TNG in intracerebral hemorrhage (ICH) has not been well studied.In the present study, we aimed to identify the prospective mechanism of TNG in treating ICH.A total of 120 mice ...
Yiqing Shen, Yuxin Ran, Ruozhi Dang
exaly   +3 more sources