Results 81 to 90 of about 240 (114)

Tenuigenin Protects Cultured Hippocampal Neurons Against Methylglyoxal-Induced Neurotoxicity

European Journal of Pharmacology, 2010
Methylglyoxal is a metabolite of glucose. Since serum methylglyoxal level is increased in diabetic patients, methylglyoxal is implicated in diabetic complications such as cognitive impairment. This study aimed to evaluate the effects of tenuigenin, an active component of roots of Polygala tenuifolia Willdenow, on methylglyoxal-induced cell injury in a ...
Yu-Jing, Chen, Xiao-Bo, Huang, Zong-Xin, Li, Lin-Lin, Yin, Wen-Qiang, Chen, Lin, Li   +5 more
exaly   +4 more sources

Protective Effects of Tenuigenin on Lipopolysaccharide and d-Galactosamine-Induced Acute Liver Injury

Microbial Pathogenesis, 2017
Tenuigenin (TEN), a major active component of polygala tenuifolia root, has been reported to have a number of biological properties, such as anti-oxidative and anti-inflammatory activities. However, the protective effect of TEN on acute liver injury has not yet been reported.
Caijun Zha
exaly   +4 more sources

Tenuigenin Down-Regulates the Release of Nitric Oxide, Matrix Metalloproteinase-9 and Cytokines From Lipopolysaccharide-Stimulated Microglia

Neuroscience Letters, 2017
Tenuigenin (TEN), an active component of Polygala tenuifolia root extracts, has been shown to provide neuroprotection in neurodegenerative disorders. To date, most of these studies have focused on the effect that TEN has on neurons. Because activated microglia can release neurotoxic factors that cause neuronal damage, the present study was designed to ...
Zheng Fan, Yan Zheng, Pingxiang Xu
exaly   +4 more sources

Tenuigenin Inhibits LPS-Induced Inflammatory Responses in Microglia via Activating the Nrf2-Mediated HO-1 Signaling Pathway

European Journal of Pharmacology, 2017
Tenuigenin (TGN), a major active component of polygala tenuifolia root, has been reported to have anti-inflammatory effect. In this study, we investigated the anti-neuroinflammatory effects of TGN on LPS-induced inflammation both in vitro and in vivo.
Yuze Cao, Qian Li, Lihua Wang
exaly   +4 more sources

Tenuigenin Ameliorates Learning and Memory Impairments Induced by Ovariectomy

Physiology and Behavior, 2013
Estrogen deficiency is associated with cognitive impairment. Hormone replacement therapy (HRT) has proven to be effective in preventing and reversing the memory and learning deficiencies. However, conventional estrogenic treatment could increase the risks of breast cancer and venous thromboembolism. Tenuigenin (TEN) is putatively believed as the active
Chu-Hua Li, Wen-Xiao Liu
exaly   +3 more sources

Tenuigenin Promotes Non-Rapid Eye Movement Sleep via the GABAA Receptor and Exerts Somnogenic Effect in a MPTP Mouse Model of Parkinson's Disease

Biomedicine and Pharmacotherapy, 2023
Sleep disturbances are commonly non-motor symptoms in Parkinson's diseases (PD). However, standard dopamine replacement therapies for the treatment of motor symptoms often prove inadequate in combating sleep disturbances. Previous studies conducted by our research group have reported the neuroprotective effects of tenuigenin, a natural extract from ...
Zheng Fan
exaly   +3 more sources

Tenuigenin Ameliorates Acute Lung Injury by Inhibiting NF-κB and MAPK Signalling Pathways

Respiratory Physiology and Neurobiology, 2015
We aimed to explore the protective effect of tenuigenin (TNG) on lipopolysaccharide (LPS)-stimulated inflammatory responses in acute lung injury (ALI). Thus, we assessed the effects of TNG on the LPS-induced production of tumour necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β in the culture supernatants of RAW 264.7 cells.
Chao Zhu, Yawen Gao, Hongming Lv
exaly   +3 more sources

Tenuigenin Treatment Improves Behavioral Y-Maze Learning by Enhancing Synaptic Plasticity in Mice

Behavioural Brain Research, 2013
Polygala tenuifolia root has been used to improve memory and cognitive function in Traditional Chinese Medicine for more than 2000 years. Since tenuigenin (TEN) is one of the most utilized P. tenuifolia root extracts, it is surprising there is no evidence for the effects of TEN on learning and memory so far.
Chu-Hua Li, Liang-Wei Gong, Jun-Ni Huang
exaly   +3 more sources

NEUROBIOLOGICAL EFFECTS OF TENUIGENIN AND THE OPPORTUNITY OF IT’S USING IN THE THERAPY OF ALZHEIMER’S AND PARKINSON’S DISEASES (LITERATURE REVIEW)

Успехи геронтологии, 2021
В обзоре представлен анализ экспериментальных и отчасти клинических данных по исследованию нейробиологических эффектов тенуигенина - важнейшего биологически активного соединения истода тонколистного (Polygala tenuifolia Willd.). Подробно описывается нейропротекторное и нейротрофическое действие данного вещества.
M A, Berezutsky, N A, Durnova, L E, Sigareva   +2 more
openaire   +3 more sources

Tenuigenin Promotes Proliferation and Differentiation of Hippocampal Neural Stem Cells

Neurochemical Research, 2011
The present study was to investigate the influence of tenuigenin, an active ingredient of Polygala tenuifolia Willd, on the proliferation and differentiation of hippocampal neural stem cells in vitro. Tenuigenin was added to a neurosphere culture and neurosphere growth was measured using MTT assay.
Yujing, Chen, Xiaobo, Huang, Wenqiang, Chen, Ningqun, Wang, Lin, Li   +4 more
openaire   +2 more sources