Results 91 to 100 of about 234 (110)

Tenuigenin targets Trim31 and NF-κB pathway to protect dopaminergic neurons in Parkinson’s disease mice

Naunyn-Schmiedeberg's Archives of Pharmacology
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the SN and the accumulation of α-synuclein (α-syn). In this study, we explored the neuroprotective effects of the natural compound tenuigenin on PD through bioinformatics analysis and in vivo experiments.
Xiaomin Wang, Xiuli Zhao, Zhang Di
exaly   +3 more sources

Tenuigenin ameliorates cognitive dysfunction in Alzheimer’s disease via hippocampal neurogenesis enhancement

Phytochemistry Letters, 2022
Kaili Lin, Xiao-Li Jiang, Shiqing Zhang   +2 more
exaly   +2 more sources

P1‐115: Effect of Tenuigenin on the Mash1 expression and directional differentiation of neural stem cells from rats hippocampi in vitro

Alzheimer's & Dementia, 2010
Xiaofeng Zhu, Jing Shi, Jinzhou Tian, Yongyan Wang   +3 more
openaire   +2 more sources

NEUROBIOLOGICAL EFFECTS OF TENUIGENIN AND THE OPPORTUNITY OF IT’S USING IN THE THERAPY OF ALZHEIMER’S AND PARKINSON’S DISEASES (LITERATURE REVIEW)

Успехи геронтологии, 2021
В обзоре представлен анализ экспериментальных и отчасти клинических данных по исследованию нейробиологических эффектов тенуигенина - важнейшего биологически активного соединения истода тонколистного (Polygala tenuifolia Willd.). Подробно описывается нейропротекторное и нейротрофическое действие данного вещества.
M A, Berezutsky, N A, Durnova, L E, Sigareva   +2 more
openaire   +3 more sources

Tenuigenin treatment decreases secretion of the Alzheimer’s disease amyloid β-protein in cultured cells

Neuroscience Letters, 2004
Amyloid beta-protein (A beta) is a pivotal pathological factor in Alzheimer's disease (AD). Tenuigenin, extracted from the Chinese herb Polygala tenuifolia, seems to ameliorate the reduction in cholinergic function on rat models induced by A beta. To examine this therapeutic effect, we tested whether Tenuigenin could inhibit secretion of A beta in ...
Hongxiao, Jia, Yong, Jiang, Yan, Ruan, Yanbo, Zhang, Xin, Ma, Jizhi, Zhang, Konrad, Beyreuther, Penfei, Tu, Dai, Zhang   +8 more
openaire   +2 more sources

Tenuigenin activates the IRS1/Akt/mTOR signaling by blocking PTPN1 to inhibit autophagy and improve locomotor recovery in spinal cord injury

Journal of Ethnopharmacology, 2023
Tenuigenin (TEN) is a main pharmacologically active component of Polygala tenuifolia Willd. (Polygalaceae), which has shown neuroprotective functions in Alzheimer's disease. Moreover, TEN also demonstrated an anti-oxidative impact in an in vitro model of Parkinson's disease, reducing damage and loss of dopaminergic neurons.This work focuses on the ...
Li'e, Zang, Dewang, Fu, Fan, Zhang, Ning, Li, Xue, Ma   +4 more
openaire   +2 more sources

Tenuigenin inhibits osteosarcoma growth via CIP2A/PP2A/NF-κB axis

Cancer Chemotherapy and Pharmacology
Polygala tenuifolia and its active components have been revealed to possess anti-tumor activities. However, the role of Tenuigenin (TEN), a bioactive ingredient from Polygala tenuifolia, in tumors such as osteosarcoma (OS) remains unclear. The present research intended to explore the efficacy and underlying mechanism of TEN on OS.OS cells were ...
Shuo, Yang, Shasha, Liu, Zixun, Dai
openaire   +2 more sources

Tenuifolin, an extract derived from tenuigenin, inhibits amyloid‐β secretion in vitro

Acta Physiologica, 2009
AbstractAim:  Previous studies have shown that tenuigenin, a crude extract of Polygala tenuifolia Willd. that is commonly used in traditional Chinese herbal medicine for memory loss, can reduce the secretion of Aβ from cultured cells. However, the mechanism underlying this effect and the active compound derived from tenuigenin is unknown. In this study,
J, Lv, H, Jia, Y, Jiang, Y, Ruan, Z, Liu, W, Yue, K, Beyreuther, P, Tu, D, Zhang   +8 more
openaire   +2 more sources

[The protective effects of tenuigenin on the PC12 cells injury induced by H2O2].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2008
To study the protective effects of tenuigenin (TEN) on the PC12 cells injury induced by H2O2.Oxidative damage PC12 cells model was induced by H2O2. The survival rate of the cells was determined by MTT method. The content of LDH was determined by ultraviolet spectrophometry and the content of MDA and SOD activity was measured respectively by ...
Gui-bo, Sun, Xiang-chao, Deng, Chu-hua, Li   +2 more
openaire   +1 more source

Tenuigenin exhibits anti-inflammatory activity via inhibiting MAPK and NF-κB and inducing Nrf2/HO-1 signaling in macrophages

Food & Function, 2016
Tenuigenin (TNG), isolated from the root of the Chinese herb Polygala tenuifolia, possesses various biological and pharmacological activities, including anti-oxidation and anti-inflammation activities.
Hongming, Lv, Wenzhi, Ren, Yuwei, Zheng, Lidong, Wang, Gejin, Lu, Pengfei, Yi, Xinxin, Ci   +6 more
openaire   +2 more sources