Results 91 to 100 of about 240 (114)

Tenuigenin Enhances Hippocampal Schaffer Collateral-CA1 Synaptic Transmission Through Modulating Intracellular Calcium

Phytomedicine, 2015
Tenuigenin (TEN), a natural product from the Chinese herb Polygala tenuifolia root, has been reported to improve cognitive function and exhibits neuroprotective effects in pharmacological studies of the central nervous system. Synaptic transmission is the essential process of brain physiological functions such as learning and memory formation, and TEN ...
Chu-Hua Li, Li Hua Yao, Jun-Ni Huang
exaly   +3 more sources

Tenuigenin Inhibits RANKL-Induced Osteoclastogenesis by Down-Regulating NF-κB Activation and Suppresses Bone Loss in Vivo

Biochemical and Biophysical Research Communications, 2015
Tenuigenin, a major active component of polygala tenuifolia root, has been used to treat patients with insomnia, dementia, and neurosis. In this study, we aimed to investigate the effects of tenuigenin on osteoclastogenesis and clarify the possible mechanism.
Hongwei Wu, Can Zhang, Xianan Li
exaly   +3 more sources

Tenuigenin treatment decreases secretion of the Alzheimer’s disease amyloid β-protein in cultured cells

Neuroscience Letters, 2004
Amyloid beta-protein (A beta) is a pivotal pathological factor in Alzheimer's disease (AD). Tenuigenin, extracted from the Chinese herb Polygala tenuifolia, seems to ameliorate the reduction in cholinergic function on rat models induced by A beta. To examine this therapeutic effect, we tested whether Tenuigenin could inhibit secretion of A beta in ...
Hongxiao, Jia, Yong, Jiang, Yan, Ruan, Yanbo, Zhang, Xin, Ma, Jizhi, Zhang, Konrad, Beyreuther, Penfei, Tu, Dai, Zhang   +8 more
openaire   +2 more sources

Tenuigenin Exhibits Protective Effects Against LPS-Induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Signaling Pathway [PDF]

European Journal of Pharmacology, 2016
Tenuigenin (TNG) has been reported to have various pharmacological activities, such as anti-oxidative and anti-inflammatory activities. However, the protective effects of TNG on lipopolysaccharides (LPS)-induced acute kidney injury (AKI) are still not clear.
Zhansheng Hu, Haiyan Fu
exaly   +3 more sources

Tenuigenin activates the IRS1/Akt/mTOR signaling by blocking PTPN1 to inhibit autophagy and improve locomotor recovery in spinal cord injury

Journal of Ethnopharmacology, 2023
Tenuigenin (TEN) is a main pharmacologically active component of Polygala tenuifolia Willd. (Polygalaceae), which has shown neuroprotective functions in Alzheimer's disease. Moreover, TEN also demonstrated an anti-oxidative impact in an in vitro model of Parkinson's disease, reducing damage and loss of dopaminergic neurons.This work focuses on the ...
Li'e, Zang, Dewang, Fu, Fan, Zhang, Ning, Li, Xue, Ma   +4 more
openaire   +2 more sources

Tenuigenin Targets Trim31 and NF-κB Pathway to Protect Dopaminergic Neurons in Parkinson’s Disease Mice

Naunyn-Schmiedeberg's Archives of Pharmacology
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the SN and the accumulation of α-synuclein (α-syn). In this study, we explored the neuroprotective effects of the natural compound tenuigenin on PD through bioinformatics analysis and in vivo experiments.
Zheng Fan, Xiu-Li Zhao
exaly   +3 more sources

Tenuifolin, an extract derived from tenuigenin, inhibits amyloid‐β secretion in vitro

Acta Physiologica, 2009
AbstractAim:  Previous studies have shown that tenuigenin, a crude extract of Polygala tenuifolia Willd. that is commonly used in traditional Chinese herbal medicine for memory loss, can reduce the secretion of Aβ from cultured cells. However, the mechanism underlying this effect and the active compound derived from tenuigenin is unknown. In this study,
J, Lv, H, Jia, Y, Jiang, Y, Ruan, Z, Liu, W, Yue, K, Beyreuther, P, Tu, D, Zhang   +8 more
openaire   +2 more sources

Tenuigenin inhibits osteosarcoma growth via CIP2A/PP2A/NF-κB axis

Cancer Chemotherapy and Pharmacology
Polygala tenuifolia and its active components have been revealed to possess anti-tumor activities. However, the role of Tenuigenin (TEN), a bioactive ingredient from Polygala tenuifolia, in tumors such as osteosarcoma (OS) remains unclear. The present research intended to explore the efficacy and underlying mechanism of TEN on OS.OS cells were ...
Shuo, Yang, Shasha, Liu, Zixun, Dai
openaire   +2 more sources

TMT-Based Quantitative Proteomics Reveals the Protective Mechanism of Tenuigenin After Experimental Intracerebral Hemorrhage in Mice

Journal of Ethnopharmacology
Tenuigenin (TNG) is an extract obtained from Polygalae Radix. It possesses anti-inflammatory, antioxidant, and neuroprotective properties. However, the potential mechanism of TNG in intracerebral hemorrhage (ICH) has not been well studied.In the present study, we aimed to identify the prospective mechanism of TNG in treating ICH.A total of 120 mice ...
Peng Xie, Yiqing Shen, Qingyuan Wu
exaly   +3 more sources

[The protective effects of tenuigenin on the PC12 cells injury induced by H2O2].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2008
To study the protective effects of tenuigenin (TEN) on the PC12 cells injury induced by H2O2.Oxidative damage PC12 cells model was induced by H2O2. The survival rate of the cells was determined by MTT method. The content of LDH was determined by ultraviolet spectrophometry and the content of MDA and SOD activity was measured respectively by ...
Gui-bo, Sun, Xiang-chao, Deng, Chu-hua, Li   +2 more
openaire   +1 more source