Results 71 to 80 of about 121,019 (277)

El papel de los factores transcripcionales en el cáncer [PDF]

, 2015
[Resumen] Las terapias génicas actuales muestran resultados prometedores en el tratamiento de diversas enfermedades, entre ellas, el cáncer. Después de los avances logrados en los últimos años en el estudio de la maquinaria transcripcional, son muchas ...
Vázquez Arias, Alba
core  

Tetrahydrobiopterin (BH4) treatment stabilizes tyrosine hydroxylase: Rescue of tyrosine hydroxylase deficiency phenotypes in human neurons and in a knock‐in mouse model

Journal of Inherited Metabolic Disease, Volume 47, Issue 3, Page 494-508, May 2024.
Abstract Proteostatic regulation of tyrosine hydroxylase (TH), the rate‐limiting enzyme in dopamine biosynthesis, is crucial for maintaining proper brain neurotransmitter homeostasis. Variants of the TH gene are associated with tyrosine hydroxylase deficiency (THD), a rare disorder with a wide phenotypic spectrum and variable response to treatment ...
Kunwar Jung‐KC, Alba Tristán‐Noguero, Altanchimeg Altankhuyag, David Piñol Belenguer, Karina S. Prestegård, Irene Fernandez‐Carasa, Arianna Colini Baldeschi, Maria Sigatulina Bondarenko, Angeles García‐Cazorla, Antonella Consiglio, Aurora Martinez   +10 more
wiley   +1 more source

Comparación de la eficacia y seguridad de la terapia combinada de cardiomioplastia celular con el factor estimulante de colonias de granulocitos en pacientes con cardiopatía isquémica en dos vías de implatación

Revista Colombiana de Cardiología, 2011
Este estudio tiene como objetivo evaluar la eficacia y seguridad de la terapia combinada de cardiomioplastia celular con el factor estimulante de colonias de granulocitos en pacientes con cardiopatía isquémica, y explorar posibles diferencias entre la ...
Juan M. Senior, MD., FACP, Clara Saldarriaga, MD, Cuéllar A. Francisco, MD, Juan D. Gómez, MD, Fabián Jaimes, MD., PhD   +4 more
doaj   +1 more source

Vetores não virais com aplicação na terapia génica: os poliplexos [PDF]

, 2016
Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de CoimbraA terapia génica representa uma grande promessa no tratamento de doenças inatas
Loureiro, Ana Patrícia Cardoso
core  

Modulation of the gut microbiome and Firmicutes phylum reduction by a nutraceutical blend in the obesity mouse model and overweight humans: A double‐blind clinical trial

Food Science &Nutrition, Volume 12, Issue 4, Page 2436-2454, April 2024.
The nutraceutical composition containing silymarin reduces the Firmicutes/Bacteroidetes ratio (F/B ratio). The nutraceutical composition of silymarin also lowers the De‐Ritis ratio, a biomarker for liver complications. The nutraceutical composition enriched with silymarin promotes an increase in Bacteroides caccae and Bacteroides uniformis, both ...
Victor Nehmi‐Filho, Jessica Alves de Freitas, Lucas Augusto Franco, Roberta Cristina Martins, José Antônio Orellana Turri, Aline Boveto Santamarina, Joyce Vanessa da Silva Fonseca, Ester Cerdeira Sabino, Bruna Carvalho Moraes, Erica Souza, Gilson Masahiro Murata, Silvia Figueiredo Costa, Paulo Sérgio Alcântara, José Pinhata Otoch, Ana Flávia Marçal Pessoa   +14 more
wiley   +1 more source

CD8+ T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?

Mediators of Inflammation, 2014
MHC-restricted CD8+ T cells are important during infection with the intracellular protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease.
Fernando dos Santos Virgilio, Camila Pontes, Mariana Ribeiro Dominguez, Jonatan Ersching, Mauricio Martins Rodrigues, José Ronnie Vasconcelos   +5 more
doaj   +1 more source

Efeito da terapia celular com células-tronco mesenquimais da medula óssea e do tecido adiposo na regeneração do tecido ósseo [PDF]

, 2020
Gabriela Guaraldo Campos Tótoli
openalex   +1 more source

Modelo de receptor de antígeno quimérico en la línea celular Jurkat [PDF]

, 2019
En este TFG se explicarán los pasos necesarios para conseguir la expresión de un receptor de antígeno quimérico (CAR) en la línea celular Jurkat, así como la generación de un doble knock-out en los genes TRAC y B2M (que codifican respectivamente para el ...
González López, Luis Alberto
core  

RETRACTED: The role of orthobiologics in chronic wound healing

International Wound Journal, Volume 21, Issue 4, April 2024.
Abstract Chronic wounds, characterized by prolonged healing processes, pose a significant medical challenge with multifaceted aetiologies, including local and systemic factors. Here, it explores the complex pathogenesis of chronic wounds, emphasizing the disruption in the normal phases of wound healing, particularly the inflammatory phase, leading to ...
Rafael Barnabé Domingues, Marita von Rautenfeld, Caroline Mayara Kavalco, Carolina Caliari, Celso Dellagiustina, Lucas Furtado da Fonseca, Fabio Ramos Costa, Andreza da Cruz Silva Reis, Gabriel Silva Santos, Gabriel Azzini, André Pinto Lemos de Faria, Napoliane Santos, Luyddy Pires, Stephany Cares Huber, Ansar Mahmood, Ignacio Dallo, Peter Everts, José Fábio Lana   +17 more
wiley   +1 more source

Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats

Neurobiology of Disease, 2012
Approximately 30% of patients with mesial temporal lobe epilepsy do not respond to treatment with antiepileptic drugs. We have previously shown that transplantation of mononuclear bone marrow cells (BMC) has an anticonvulsant effect in acute epilepsy ...
Zaquer S.M. Costa-Ferro, Bruno S.F. Souza, Marcos M.T. Leal, Carla Martins Kaneto, Carine Machado Azevedo, Igor Campos da Silva, Milena B.P. Soares, Ricardo Ribeiro-dos-Santos, Jaderson C. DaCosta   +8 more
doaj   +1 more source