Results 51 to 60 of about 4,253 (175)

Enzymatic Poly(gallic acid)‐grafted L‐Histidine Reduces Cell Inflammation and Oxidative Stress: In Silico and In Vitro Studies

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
Microwave‐assisted grafting yields a PGAL–His conjugate with enhanced binding through electrostatic and hydrogen‐bond interactions. The material modulates THP‐1 macrophage response, reducing ROS production, pro‐inflammatory cytokines (IL‐6, IL‐1β, TNF‐α), and cell adhesion.
Carmen G. Hernández‐Valencia, Iris N. Serratos, Carlos M. Torre‐Morales, Rosa Isela Ortiz‐Huidobro, Alfredo Vázquez, José Pedraza‐Chaverri, Valentín Martínez‑López, Javier Fernández‑Torres, Roberto Sánchez‑Sánchez, Yessica Zamudio‑Cuevas, Miquel Gimeno   +10 more
wiley   +1 more source

Prolonged Release of IL‐10 From Enzyme‐Mediated Poly‐l‐(Tyrosine‐co‐Phenylalanine) Nanocrystals Enhances Stability and Modulates Inflammatory Responses

Biopolymers, Volume 117, Issue 2, March 2026.
Schematic representation of enzyme‐mediated peptide nanocrystal formation and IL‐10 encapsulation, providing stabilized and sustained cytokine delivery that modulates macrophage phenotype and reduces inflammatory responses. ABSTRACT Protease‐catalyzed synthesis of a peptide composed of l‐tyrosine and l‐phenylalanine (2.2:1 M ratio) was achieved in a ...
Fátima Landa‐Tencle, Carmen G. Hernández‐Valencia, Fernando Guzmán‐Lagunes, Carmina Montiel, Yoan Cuellar‐Entenza, Carlos Guerrero‐Sánchez, Steffi Stumpf, Stephanie Hoeppener, Ulrich S. Schubert, Yessica Zamudio‐Cuevas, Roberto Sánchez‐Sánchez, Miquel Gimeno   +11 more
wiley   +1 more source

Mineralizing Elastin‐Like Protein Microgels

Journal of Biomedical Materials Research Part A, Volume 113, Issue 12, December 2025.
ABSTRACT Mineralized tissues, such as bone and enamel are fundamental to the structure and function of organisms, with a complex interplay between their organic and inorganic components. Organized mineralization is crucial for both the tissues of living organisms and engineered materials.
Ieva Sapjanskaite, Abshar Hasan, José Carlos Rodríguez‐Cabello, Christopher Parmenter, Michael W. Fay, Christabel Fowler, Cameron Alexander, Alvaro Mata   +7 more
wiley   +1 more source

T cell receptor signaling pathway is overexpressed in CD4+ T cells from HAM/TSP individuals

Brazilian Journal of Infectious Diseases, 2015
Human T-lymphotropic virus type 1 (HTLV-1) is a human retrovirus related to the chronic neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4+ T cells activation appears to play a key role on HTLV-1 infection.
Mariana Tomazini Pinto, Tathiane Maistro Malta, Evandra Strazza Rodrigues, Osvaldo Massaiti Takayanagui, Yuetsu Tanaka, Dimas Tadeu Covas, Simone Kashima   +6 more
doaj   +1 more source

Autologous adipose-derived mesenchymal stem cell therapy reverses detrusor underactivity: open clinical trial

Stem Cell Research & Therapy, 2023
Background Detrusor underactivity is a disease that can cause chronic urinary tract infection, urinary tract infection, urinary retention and kidney failure and has no effective treatment in traditional medicine.
Henrique Rodrigues Scherer Coelho, Silvia Cordeiro das Neves, Jovino Nogueira da Silva Menezes, Andréia Conceição Milan Brochado Antoniolli-Silva, Rodrigo Juliano Oliveira   +4 more
doaj   +1 more source

Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic Chagas disease cardiomyopathy

Scientific Reports, 2017
Chagas disease cardiomyopathy is a parasite-driven inflammatory disease to which there are no effective treatments. Here we evaluated the therapeutic potential of N,N-dimethylsphingosine(DMS), which blocks the production of sphingosine-1-phosphate(S1P ...
Juliana Fraga Vasconcelos, Cássio Santana Meira, Daniela Nascimento Silva, Carolina Kymie Vasques Nonaka, Pâmela Santana Daltro, Simone Garcia Macambira, Pablo Daniel Domizi, Valéria Matos Borges, Ricardo Ribeiro-dos-Santos, Bruno Solano de Freitas Souza, Milena Botelho Pereira Soares   +10 more
doaj   +1 more source

Adaptive Elastin‐Like Hydrogel with Unidirectional and Controllable Anisotropic Actuation for Soft Robotics and Tissue Engineering

Advanced Materials Technologies, Volume 10, Issue 17, September 4, 2025.
Fiber‐reinforced elastin‐like tubular scaffolds are engineered to achieve anisotropic and reversible actuation under external stimuli. By adjusting fiber's angle, actuation behavior is finely tuned, enabling distinct actuation responses, even within different regions of the same scaffold.
Federica Sallustio, Amanda Schmidt, Ikram El Maachi, Alexander Greenhalgh, Martin Frydrych, Stefan Jockenhoevel, José Carlos Rodríguez‐Cabello, Alicia Fernández‐Colino   +7 more
wiley   +1 more source

CD8+ T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?

Mediators of Inflammation, 2014
MHC-restricted CD8+ T cells are important during infection with the intracellular protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease.
Fernando dos Santos Virgilio, Camila Pontes, Mariana Ribeiro Dominguez, Jonatan Ersching, Mauricio Martins Rodrigues, José Ronnie Vasconcelos   +5 more
doaj   +1 more source

Comparación de la eficacia y seguridad de la terapia combinada de cardiomioplastia celular con el factor estimulante de colonias de granulocitos en pacientes con cardiopatía isquémica en dos vías de implatación

Revista Colombiana de Cardiología, 2011
Este estudio tiene como objetivo evaluar la eficacia y seguridad de la terapia combinada de cardiomioplastia celular con el factor estimulante de colonias de granulocitos en pacientes con cardiopatía isquémica, y explorar posibles diferencias entre la ...
Juan M. Senior, MD., FACP, Clara Saldarriaga, MD, Cuéllar A. Francisco, MD, Juan D. Gómez, MD, Fabián Jaimes, MD., PhD   +4 more
doaj   +1 more source

The role of the endogenous opioid system in modulating orthodontic‐induced neurogenic inflammation of the dental pulp: A comprehensive review of the literature

International Endodontic Journal, Volume 58, Issue 8, Page 1126-1145, August 2025.
Abstract Background Orthodontic forces may lead to neurogenic inflammation in the dental pulp by triggering the release of somatosensory neuropeptides such as Substance P (SP), Calcitonin gene‐related peptide (CGRP) and Neurokinin A (NKA). In the vast majority of patients, acute symptoms are not triggered, probably due to the control of the neurogenic ...
Javier Caviedes‐Bucheli, Nestor Rios‐Osorio, Esteban Ulate‐Rodríguez, Hernan Dario Muñoz‐Alvear, José F. Gaviño‐Orduña, P. Sebastian Ortolani‐Seltenerich, Jose F. Gomez‐Sosa, Hugo Roberto Munoz   +7 more
wiley   +1 more source