Results 1 to 10 of about 1,093,681 (262)

Enhanced cellular therapy: revolutionizing adoptive cellular therapy. [PDF]

Exp Hematol Oncol
AbstractEnhanced cellular therapy has emerged as a novel concept following the basis of cellular therapy. This treatment modality applied drugs or biotechnology to directly enhance or genetically modify cells to enhance the efficacy of adoptive cellular therapy (ACT).
Xu MY, Zeng N, Liu CQ, Sun JX, An Y, Zhang SH, Xu JZ, Zhong XY, Ma SY, He HD, Hu J, Xia QD, Wang SG.   +12 more
europepmc   +4 more sources

Mimicking Myelodysplastic Syndrome: Importance of Differential Diagnosis

Case Reports in Hematology, 2021
Copper deficiency is a rare nutritional deficiency with hematological manifestations that mimic those found in myelodysplastic syndrome, a hematological malignancy incurable without allogeneic hematopoietic stem cell transplantation.
Thomas Luo, Joanna Zurko, John Astle, Nirav N. Shah   +3 more
doaj   +1 more source

Enalaprilat and losartan decrease erythroid precursors frequency in cells from patients with polycythemia vera

Hematology, 2023
Objective: Polycythemia Vera (PV) is a myeloproliferative neoplasm characterized by the overproduction of red blood cells. First-line therapies are directed at lowering hematocrit levels. After the discovery of a mutation in the Janus kinase 2 (JAK2V617F)
Angela Bozza, Martina Bernardi, Daniela Catanzaro, Katia Chieregato, Anna Merlo, Giuseppe Astori   +5 more
doaj   +1 more source

Improved outcomes of high-risk relapsed Hodgkin lymphoma patients after high-dose chemotherapy: a 15-year analysis

Haematologica, 2021
High-dose chemotherapy and autologous stem-cell transplant (HDC/ASCT) is standard treatment for chemosensitive relapsed classical Hodgkin lymphoma, although outcomes of high-risk relapse (HRR) patients remain suboptimal.
Yago Nieto, Stephen Gruschkus, Benigno C. Valdez, Roy B. Jones, Paolo Anderlini, Chitra Hosing, Uday Popat, Muzaffar Qazilbash, Partow Kebriaei, Amin Alousi, Neeraj Saini, Samer Srour, Katayoun Rezvani, Jeremy Ramdial, Melissa Barnett, Alison Gulbis, Terri Lynn Shigle, Sairah Ahmed, Swaminathan Iyer, Hun Lee, Ranjit Nair, Simrit Parmar, Raphael Steiner, Bouthaina Dabaja, Chelsea Pinnix, Jillian Gunther, Branko Cuglievan, Kris Mahadeo, Sajad Khazal, Hubert Chuang, Richard Champlin, Elizabeth J. Shpall, Borje S. Andersson   +32 more
doaj   +1 more source

In Vitro FVIII-Encoding Transgenic Mesenchymal Stem Cells Maintain Successful Coagulation in FVIII-Deficient Plasma Mimicking Hemophilia A

Turkish Journal of Hematology, 2023
Objective: Hemophilia A is an X-linked recessive bleeding disorder caused by a deficiency of plasma coagulation factor VIII (FVIII), and it accounts for about 80%-85% of all cases of hemophilia.
Cansu Hemşinlioğlu, Elif Sibel Aslan, Cihan Tastan, Didem Çakırsoy, Raife Dilek Turan, Utku Seyis, Muhammer Elek, Gözde Sır Karakuş, Ömür Selin Günaydın, Selen Abanuz, Derya Dilek Kançağı, Bulut Yurtsever, Koray Yalçın, Murat Kasap, Ercüment Ovalı   +14 more
doaj   +1 more source

Cellular therapy in Tuberculosis [PDF]

International Journal of Infectious Diseases, 2015
Cellular therapy now offer promise of potential adjunct therapeutic options for treatment of drug-resistant tuberculosis (TB). We review here the role of Mesenchymal stromal cells, (MSCs), as well as other immune effector cells in the therapy of infectious diseases with a focus on TB.
Shreemanta K. Parida, Rajhmun Madansein, Nalini Singh, Nesri Padayatchi, Iqbal Master, Kantharuben Naidu, Alimuddin Zumla, Markus Maeurer   +7 more
openaire   +3 more sources

Preclinical Evaluation of the Tumorigenic and Immunomodulatory Properties of Human Bone Marrow Mesenchymal Stromal Cell Populations with Clonal Trisomy 5

Stem Cells International, 2022
Cytogenetic aberrations may emerge in human mesenchymal stromal cells (MSC) during ex vivo expansion for cell therapy. We have detected clonal trisomy 5 in two distinct autologous MSC products expanded from bone marrow which, based on the current quality
Maria Susana Joya Marodin, Juliana A. Godoy, Raquel M. Alves-Paiva, Kelen Alvarez, Thiago Giove Mitsugi, Ana Cristina Victorino Krepischi, Nelson Hamerschlak, Maria Augusta Tezelli Bortolini, Rodrigo Castro, Andrea T. Kondo, Jose Mauro Kutner, Oswaldo Keith Okamoto   +11 more
doaj   +1 more source

Imaging of cellular therapies

Advanced Drug Delivery Reviews, 2010
Cellular therapy promises to revolutionize medicine, by restoring tissue and organ function, and combating key disorders including cancer. As with all major developments, new tools must be introduced to allow optimization. For cell therapy, the key tool is in vivo imaging for real time assessment of parameters such as cell localization, numbers and ...
Srinivas, M., Aarntzen, E.H.J.G., Bulte, J.W., Oyen, W.J.G., Heerschap, A., de Vries, I.J.M., de Vries, I.J.M., de Vries, I.J.M., Figdor, C.G.   +8 more
openaire   +4 more sources

Cellular Therapies for Immunosuppression [PDF]

, 2012
Almost all current therapeutic approaches to inhibit destructive immune responses in autoimmunity are based on antigen non-specific agents, such as cyclosporine A, which systemically suppress the function of virtually all immune effector cells.
Cools, Nathalie, Van Tendeloo, Viggo F.I., Berneman, Zwi N.   +2 more
openaire   +2 more sources

Cellular metabolism therapy

Journal of Translational Medicine, 2022
No abstract ...
openaire   +4 more sources