Results 11 to 20 of about 1,741,500 (304)

Cellular Therapies for Immunosuppression [PDF]

, 2012
Almost all current therapeutic approaches to inhibit destructive immune responses in autoimmunity are based on antigen non-specific agents, such as cyclosporine A, which systemically suppress the function of virtually all immune effector cells.
Cools, Nathalie, Van Tendeloo, Vigor, Berneman, Zwi Nisan   +2 more
openaire   +2 more sources

Preclinical efficacy and safety analysis of gamma-irradiated inactivated SARS-CoV-2 vaccine candidates

Scientific Reports, 2021
COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, SARS-CoV-2 vaccines have become crucial for reducing morbidity and mortality.
Gozde Sir Karakus, Cihan Tastan, Derya Dilek Kancagi, Bulut Yurtsever, Gamze Tumentemur, Sevda Demir, Raife Dilek Turan, Selen Abanuz, Didem Cakirsoy, Utku Seyis, Samed Ozer, Omer Elibol, Muhammer Elek, Gurcan Ertop, Serap Arbak, Merve Acikel Elmas, Cansu Hemsinlioglu, Ayse Sesin Kocagoz, Ozden Hatirnaz Ng, Sezer Akyoney, Ilayda Sahin, Ugur Ozbek, Dilek Telci, Fikrettin Sahin, Koray Yalcin, Siret Ratip, Ercument Ovali   +26 more
doaj   +1 more source

How CAR T Cells Breathe

Cells, 2022
The manufacture of efficacious CAR T cells represents a major challenge in cellular therapy. An important aspect of their quality concerns energy production and consumption, known as metabolism.
Christopher Forcados, Sandy Joaquina, Nicholas Paul Casey, Benjamin Caulier, Sébastien Wälchli   +4 more
doaj   +1 more source

UVA Assisted 4-Thiothymidine for Cancer Treatment [PDF]

, 2016
This article reviews the developments of 4-thiothymidine analogues, assisted with UVA light, as a novel cancer therapy. First, the key points on synthetic chemistry, photochemistry and cellular toxicity of 4-thiothymidine are summarized.
Feng, Luo, Ge, Jiang, Xiaohui, Zhang, Yaozhong, Xu   +3 more
core   +1 more source

Cellular metabolism therapy

Journal of Translational Medicine, 2022
No abstract ...
openaire   +4 more sources

Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice

Stem Cell Research & Therapy, 2017
Background Radiation exposure poses a significant threat to public health. Hematopoietic injury is one of the major manifestations of acute radiation sickness.
Pasupathi Sundaramoorthy, Qinhong Wang, Zhihong Zheng, Yiqun Jiao, Benny J. Chen, Phuong L. Doan, Nelson J. Chao, Yubin Kang   +7 more
doaj   +1 more source

Regression of murine lung tumors by the let-7 microRNA. [PDF]

, 2010
MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer.
Bader, AG, Brown, D, Homer, R, Kelnar, K, Medina, PP, Omotola, M, Ruffino, L, Slack, FJ, Trang, P, Weidhaas, JB, Wiggins, JF   +10 more
core   +2 more sources

Preliminary report of in vitro and in vivo effectiveness of dornase alfa on SARS-CoV-2 infection

New Microbes and New Infections, 2020
Dornase alfa, the recombinant form of the human DNase I enzyme, breaks down neutrophil extracellular traps (NET) that include a vast amount of DNA fragments, histones, microbicidal proteins and oxidant enzymes released from necrotic neutrophils in the ...
H.K. Okur, K. Yalcin, C. Tastan, S. Demir, B. Yurtsever, G.S. Karakus, D.D. Kancagi, S. Abanuz, U. Seyis, R. Zengin, C. Hemsinlioglu, M. Kara, M.E. Yildiz, E. Deliceo, N. Birgen, N.B. Pelit, C. Cuhadaroglu, A.S. Kocagoz, E. Ovali   +18 more
doaj   +1 more source

Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming. [PDF]

, 2016
The impact of EGFR-mutant NSCLC precision therapy is limited by acquired resistance despite initial excellent response. Classic studies of EGFR-mutant clinical resistance to precision therapy were based on tumor rebiopsies late during clinical tumor ...
Bagai, Rakesh, Bivona, Trever G, Danielpour, David, Feng, Yan, Leahy, Patrick, Lindner, Daniel, Ma, Patrick C, Rosell, Rafael, Shi, Ivy, Thiagarajan, Praveena S, Veigl, Martina, Wu, Xiaoliang, Yin, Lihong, Zhang, Wei, Zhang, Zhenfeng   +14 more
core   +1 more source

Factors influencing transfusion-associated HLA sensitization in patients bridged to heart transplantation using ventricular assist device. [PDF]

, 2020
BackgroundBridging heart failure patients with mechanical ventricular assist devices (VAD) enables access to transplantation. However, VAD is associated with increased risk for anti-HLA antibodies associated with rejection of subsequent allografts ...
Adler, Eric, Elkind, Jae, Morris, Gerald P, Ostberg-Braun, Oscar, Silva Enciso, Jorge, Sobczyk, Juliana   +5 more
core   +1 more source