Results 41 to 50 of about 121,422 (225)

Establishment of a simple and efficient platform for car-t cell generation and expansion: from lentiviral production to in vivo studies

open access: yesHematology, Transfusion and Cell Therapy, 2020
Introduction: Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19 + B-cell malignancies in numerous clinical trials. The CAR molecule, which recognizes cell-
Virgínia Picanço-Castro   +11 more
doaj   +1 more source

Bases da terapia celular em cardiologia [PDF]

open access: yesRevista Brasileira de Hematologia e Hemoterapia, 2009
O implante de celulas para o tratamento de doencas cardiovasculares encontra-se sob investigacao em varios centros no mundo. Varias linhagens celulares, de celulas-tronco bem caracterizadas a fracoes contendo diferentes tipos de celulas, tem sido investigadas em modelos animais.
Carvalho, Antonio Carlos C.   +3 more
openaire   +3 more sources

A proof-of-concept clinical trial using mesenchymal stem cells for the treatment of corneal epithelial stem cell deficiency [PDF]

open access: yes, 2019
Producción CientíficaOcular stem cell transplantation derived from either autologous or allogeneic donor corneoscleral junction is a functional cell therapy to manage extensive and/or severe limbal stem cell deficiencies that lead to corneal epithelial ...
Alberca Zaballos, Mercedes   +9 more
core   +2 more sources

Targeting the Immune System With Mesenchymal Stromal Cell-Derived Extracellular Vesicles: What Is the Cargo's Mechanism of Action?

open access: yesFrontiers in Bioengineering and Biotechnology, 2019
The potent immunomodulatory activities displayed by mesenchymal stromal cells (MSCs) have motivated their application in hundreds of clinical trials to date.
Jorge Diego Martin-Rufino   +6 more
doaj   +1 more source

The Brazilian association of hematology, hemotherapy, and cell therapy (ABHH) and its absolute commitment to ethics and absence of conflicts of interest [PDF]

open access: yesHematology, Transfusion and Cell Therapy
Carmino Antonio de Souza   +15 more
doaj   +2 more sources

EXPERIÊNCIA DE UM SERVIÇO DE IMUNO-HEMATOLOGIA NA RESOLUÇÃO DE UM CASO COMPLEXO COM ANTICORPOS ANTI-HY E ANTI- JOA

open access: yesHematology, Transfusion and Cell Therapy
Introdução: Os serviços de imuno-hematologia enfrentam diariamente desafios na identificação de anticorpos irregulares, sobretudo se envolve anticorpos contra antígenos de alta frequência.
GL Oliveira   +9 more
doaj   +1 more source

An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids

open access: yesAdvanced Materials Technologies, EarlyView.
This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto   +6 more
wiley   +1 more source

Clinical Translation of Mesenchymal Stromal Cell Therapy for Graft Versus Host Disease

open access: yesFrontiers in Cell and Developmental Biology, 2019
Graft versus host disease (GVHD) is a common condition in patients subjected to allogeneic hematopoietic stem cell transplantation (HSCT). The immune cells derived from the grafted stem cells attack recipient’s tissues, including those from the skin ...
Juliana A. P. Godoy   +6 more
doaj   +1 more source

Prospective implementation of the HCT frailty scale in adults with lymphoproliferative syndromes candidates for autologous haematopoietic stem cell transplantation: Results from a multicentre GETH‐TC study

open access: yesBritish Journal of Haematology, EarlyView.
Summary This prospective study evaluated the incidence and dynamics of frailty in 156 adults with lymphoproliferative syndromes undergoing autologous haematopoietic stem cell transplantation (HSCT). Frailty was assessed using the haematopoietic cell transplantation (HCT) frailty scale in patients from 15 Spanish institutions at initial consultation ...
Javier Cornago   +30 more
wiley   +1 more source

A pilot study of the effects of hormone therapy on normal breast tissue of postmenopausal women [PDF]

open access: yes, 2006
PURPOSE: to analyze breast tissue of postmenopausal women before and after six months of continuous combined estrogen-progestin replacement therapy (0.625 mg conjugated equine estrogens associated with 2.5 mg medroxyprogesterone acetate).
Baracat, Edmund Chada   +6 more
core   +3 more sources

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