Results 31 to 40 of about 4,236 (180)

Regulamentação das terapias celulares no Brasil

Vigilância Sanitária em Debate, 2014
Este estudo buscou realizar um levantamento da legislação sobre as terapias com células-tronco a nível nacional e internacional. Buscou-se também discutir a abordagem de tratamento que poderá ser adotada para a regulamentação das terapias celulares no Brasil.
Luciana Narahashi, Antonio Carlos Campos de Carvalho, Humberto Pinheiro de Araújo   +2 more
openaire   +5 more sources

ENHANCED ANTI-TUMOR ACTIVITY OF CD19.CAR-NK CELLS BY INCORPORATING IL-27

Hematology, Transfusion and Cell Therapy, 2023
Autologous T-cells expressing Chimeric Antigen Receptor (CAR) have shown great efficacy against hematologic malignancies, however, severe side effects limit their clinical use.
AFB Biggi, RN Silvestre, JTC Azevedo, MC Tirapelle, KCR Malmegrim, ML Figueiredo, DT Covas, V Picanço-Castro   +7 more
doaj   +1 more source

The role of bone marrow mononuclear cell-conditioned medium in the proliferation and migration of human dermal fibroblasts

Cellular & Molecular Biology Letters, 2017
Background Several recent studies have demonstrated the great potential of bone marrow cells in regenerative medicine, not only for their ability to differentiate to match a damaged cell type, but also because they synthesize and release various growth ...
Yolanda Menéndez-Menéndez, Jesús Otero-Hernández, Jose Antonio Vega, Marcos Pérez-Basterrechea, Silvia Pérez-López, María Álvarez-Viejo, Amaia Ferrero-Gutiérrez   +6 more
doaj   +1 more source

ANÁLISE DOS RESULTADOS OBTIDOS COM O USO DO PLERIXAFOR PARA O RESGASTE DAS MOBILIZAÇÕES NO TRANSPLANTE DE CÉLULAS PROGENITORAS HEMATOPOIÉTICAS (CPHS) AUTÓLOGO

Hematology, Transfusion and Cell Therapy
Introdução: Para o transplante autólogo, a fonte de escolha para a coleta de CPHs é o sangue periférico mobilizado. A mobilização acontece através da administração do fator estimulador de colônias de granulócitos (G-CSF) por 4 dias consecutivos.
MP Santos, CHC Ribeiro, PDC Machado, DR Vidal, JPR Azevedo   +4 more
doaj   +1 more source

Both CD133 Cells and Monocytes Provide Significant Improvement for Hindlimb Ischemia, Although They do not Transdifferentiate Into Endothelial Cells

Cell Transplantation, 2010
To address a number of questions regarding the experimental use of bone marrow (BM) stem cells in hindlimb ischemia, including which is the best cell type (e.g., purified hematopoietic stem cell or monocytes), the best route of delivery [intramuscular ...
Fermin M. Sanchez-Guijo M.D., PhD., Enrique Oterino, Maria-Victoria Barbado, Soraya Carrancio, Natalia Lopez-Holgado, Sandra Muntion, Pilar Hernandez-Campo, Luis-Ignacio Sanchez-Abarca, Jose A. Perez-Simon, Jesús F. San Miguel, Jesús G. Briñon, Maria-Consuelo Del Cañizo   +11 more
doaj   +1 more source

Establishment of a simple and efficient platform for car-t cell generation and expansion: from lentiviral production to in vivo studies

Hematology, Transfusion and Cell Therapy, 2020
Introduction: Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19 + B-cell malignancies in numerous clinical trials. The CAR molecule, which recognizes cell-
Virgínia Picanço-Castro, Pablo Diego Moço, Amanda Mizukami, Leticia Delfini Vaz, Marcelo de Souza Fernandes Pereira, Renata Nacasaki Silvestre, Júlia Teixeira Cottas de Azevedo, Aline de Sousa Bomfim, Mario Soares de Abreu Neto, Kelen Cristina Ribeiro Malmegrim, Kamilla Swiech, Dimas Tadeu Covas   +11 more
doaj   +1 more source

Bases da terapia celular em cardiologia [PDF]

Revista Brasileira de Hematologia e Hemoterapia, 2009
O implante de celulas para o tratamento de doencas cardiovasculares encontra-se sob investigacao em varios centros no mundo. Varias linhagens celulares, de celulas-tronco bem caracterizadas a fracoes contendo diferentes tipos de celulas, tem sido investigadas em modelos animais.
Carvalho, Antonio Carlos C., Goldenberg, Regina Coeli S., Tuche, Fábio Antonio A., Dohmann, Hans Fernando R.   +3 more
openaire   +3 more sources

Targeting the Immune System With Mesenchymal Stromal Cell-Derived Extracellular Vesicles: What Is the Cargo's Mechanism of Action?

Frontiers in Bioengineering and Biotechnology, 2019
The potent immunomodulatory activities displayed by mesenchymal stromal cells (MSCs) have motivated their application in hundreds of clinical trials to date.
Jorge Diego Martin-Rufino, Jorge Diego Martin-Rufino, Natalia Espinosa-Lara, Lika Osugui, Fermin Sanchez-Guijo, Fermin Sanchez-Guijo, Fermin Sanchez-Guijo   +6 more
doaj   +1 more source

EXPERIÊNCIA DE UM SERVIÇO DE IMUNO-HEMATOLOGIA NA RESOLUÇÃO DE UM CASO COMPLEXO COM ANTICORPOS ANTI-HY E ANTI- JOA

Hematology, Transfusion and Cell Therapy
Introdução: Os serviços de imuno-hematologia enfrentam diariamente desafios na identificação de anticorpos irregulares, sobretudo se envolve anticorpos contra antígenos de alta frequência.
GL Oliveira, EJ Sekiya, ALD Santos, CRCS Kugler, EM Silva, IGV Seco, JCS Pimentel, RA Cardoso, MCAV Conrado, A Alves   +9 more
doaj   +1 more source

An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids

Advanced Materials Technologies, EarlyView.
This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto, Manuel Alejandro Vazquez Valle, Mitzi Pérez‐Calixto, Cindy Peto‐Gutiérrez, Iván Velasco, Genaro Vázquez‐Victorio, Itzel Escobedo‐Avila   +6 more
wiley   +1 more source