Results 21 to 30 of about 26,590 (258)

Teratogenic effects of antiepileptic drugs [PDF]

Expert Review of Neurotherapeutics, 2010
Many antiepileptic drugs (AEDs) have therapeutic applications that extend beyond epilepsy to include neuropathic pain, migraine headaches and psychiatric disorders. The risk of some AEDs has been clearly established, but for newer drugs, small sample sizes and polytherapy exposures preclude a conclusive determination of their teratogenic potential ...
Denise S, Hill, Bogdan J, Wlodarczyk, Ana M, Palacios, Richard H, Finnell   +3 more
openaire   +2 more sources

Zebrafish and Artemia salina in vivo evaluation of the recreational 25C-NBOMe drug demonstrates its high toxicity

Toxicology Reports, 2021
The NBOMe (N-2-methoxybenzyl-phenethylamines) family of compounds are synthetic hallucinogens derived from the 2C series. Although this family of compounds has been responsible for multiple cases of acute toxicity and several deaths around the world, to ...
Natalie Álvarez-Alarcón, Jhon Jairo Osorio-Méndez, Adis Ayala-Fajardo, William F. Garzón-Méndez, Zayra V. Garavito-Aguilar   +4 more
doaj   +1 more source

Efeitos de extratos de Nierembergia veitchii (Hook) Solanaceae sobre a fertilidade de ratas e morfologia óssea dos fetos The effects of Nierembergia veitchii (Hook) Solanaceae extracts in rat fertility and fetal skeleton morphology

Ciência Rural, 2000
Os efeitos da administração oral dos extratos aquoso (NvH2O), metanólico (NvmeOH), butanólico (Nvbut) e hexano (Nvhex), obtidos, seqüencialmente, de 500g de Nierembergia veitchii (planta seca), foram comparados aos obtidos com vitamina D3 (2,5mg.kg-1) e ...
João Roberto Braga de Mello, Augusto Langeloh, Gerhard Habermehl, Hans Krebs, Fernanda Bastos, Fernanda Alvares   +5 more
doaj   +1 more source

Unsymmetrical dimethylhydrazine (UDMH) exposure to zebrafish embryos causes lethal and severe teratogenic effects [PDF]

BIO Web of Conferences
The assessment of lethal and teratogenic effects of unsymmetrical dimethylhydrazine (UDMH) using zebrafish embryo toxicity test for 72 h was performed. Following UDMH concentrations were studied for embryotoxic effects: 0.64M, 0.13M, 0.06M, 0.04M, 5x10 ...
Suvorova Mariya, Sailaubekova Pakizat, Biyasheva Zarema, Zharkova Irina, Abdullayeva Bagila   +4 more
doaj   +1 more source

Retinoids – A Perspective To Teratogenic Effects

Journal of Dentistry Indonesia, 2015
Since the role of retinoids in normal growth, reproduction, maintenance and differentiantion of epithelial tissue has been known, the therapeutic value of retinoids has been utilised in disorders resembling vitamin A (retinol) deficiency. Much effort has
Elza Ibrahim Auerkari
doaj   +1 more source

Possible Teratogenic Effects of Veratramine

Experimental Biology and Medicine, 1966
SummaryThe alkaloid veratramine, a parent alkamine of the steroidal class of veratrum alkaloids, produced congenital abnormalities in lambs. It did not produce the expected cyclopian deformities but rather abnormalities which included slight lateral or medial bowing of the front legs, slight to marked flexure of knee joint, looseness of the hock or ...
R F, Keeler, W, Binns
openaire   +2 more sources

Knowledge regarding teratogens among women of childbearing age at a large tertiary care center in Saudi Arabia

Journal of Family Medicine and Primary Care, 2020
Aim: To investigate the knowledge of Saudi women regarding the teratogenic effects of environmental agents such as fever, some chronic conditions and medications and its association with certain socio-demographic factors.
Wejdan Alhamdan, Afaf Moukaddem, Nourh AlOtaibi, Adibah Aledrees, Nada Alhatem, Nada Alshehri, Samaher Alfaraj, Maysoon Aladham   +7 more
doaj   +1 more source

Teratogenic effect of carbamazepine. [PDF]

Archives of Disease in Childhood, 1991
A girl was born to a mother who had undergone treatment for epilepsy with carbamazepine during pregnancy. The infant had dysmorphic features and was physically and mentally retarded. We consider that the malformations were the result of the maternal treatment with carbamazepine.
V, Vestermark, S, Vestermark
openaire   +2 more sources

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source