Results 71 to 80 of about 10,172 (300)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside [PDF]

Terbium features four clinically interesting radionuclides for application in nuclear medicine: terbium-149, terbium-152, terbium-155, and terbium-161.
Ooms, Maarten, Van Laere, Camille, Cocolios, Thomas E, Cleeren, Frederik, Koole, Michel, Baete, Kristof, Deroose, Christophe M, Duchemin, Charlotte, de Voorde, Michiel Van   +8 more
core   +1 more source

Synthesis and properties of thin films made from suspension on the basis of powder composite yttrium aluminum, doped with terbium

Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019
The results of synthesis and analysis of the film structures fabricated from suspensions based on titanium dioxide sol and terbium-doped yttrium aluminum composite powder are presented.
L. S. Khoroshko, M. V. Rudenko, A. V. Kryvasheyeu, M. V. Meledina, N. V. Gaponenko, T. F. Raichyonok, S. A. Tikhomirov   +6 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Magneto-elastic interactions in terbium [PDF]

, 1971
Making use of the Hamiltonian for linear magneto-elastic coupling which has been proposed by Callen and Callen, expressions are deduced for changes in the velocity of acoustic waves in a terbium crystal, due to ferromagnetic ordering and the application ...
Jensen, J.
core  

A Simple Attitude Unscented Kalman Filter: Theory and Evaluation in a Magnetometer-Only Spacecraft Scenario

IEEE Access, 2016
A quaternion-based attitude unscented Kalman filter is formulated with quaternion errors parameterized by small angle approximations and is applied to a filter with a state vector consisting of the attitude quaternion and the gyro bias vector. The filter
Murty S. Challa, Jay G. Moore, Daniel J. Rogers   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Synthesis and structure of hydrated terbium carbonate [PDF]

, 1996
992-994Crystalline terbium carbonate has been synthesized using ammonium bicarbonate as a precipitant. The X-ray diffraction data have been indexed and these indicate a monoclinic system with cell parameters, a= 18.745Å, b= 14.244Å, c= 15.329Å and β = 95.
Song, Liu, Rongjun, Ma
core