Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Constrained Fourier estimation of short-term time-series gene expression data reduces noise and improves clustering and gene regulatory network predictions. [PDF]
BMC Bioinformatics, 2022 Bar N +3 more
europepmc +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
What do nurses want? critical factors in recruiting and retaining RNs in long-term care
, 1992 Title from cover of PDF document (viewed June 27, 2005); at head of title: Ohio Long-Term Care Research Project.; "January 1992."; Includes bibliographical references (p.
Ohio Long-Term Care Research Project. +1 more
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A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Do We Experience Events in Terms of Time or Time in Terms of Events?
Journal of Vision, 2010 B. M. Liverence, B. J. Scholl
openaire +1 more source
Integrating term-time working into graduate employability development strategies [PDF]
, 2002 Government at the time of this project was seeking to improve graduate employability. With work placements for undergraduates struggling to keep up with the expansion in student numbers, term-time working can potentially provide a significant source of ...
Stone, Ian, Fitzgerald, Ian
core
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Alternative adjustment for seasonality and long-term time-trend in time-series analysis for long-term environmental exposures and disease counts. [PDF]
BMC Med Res Methodol, 2021 Kim H, Lee JT, Fong KC, Bell ML.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source