Results 131 to 140 of about 21,600,368 (295)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Development of a long-term time-weighted exposure metric that accounts for missing data in the Seychelles Child Development Study. [PDF]

Neurotoxicology, 2022
Thurston SW, Harrington D, Mruzek DW, Shamlaye C, Myers GJ, van Wijngaarden E.   +5 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Purifying Selection Determines the Short-Term Time Dependency of Evolutionary Rates in SARS-CoV-2 and pH1N1 Influenza. [PDF]

Mol Biol Evol, 2022
Ghafari M, du Plessis L, Raghwani J, Bhatt S, Xu B, Pybus OG, Katzourakis A.   +6 more
europepmc   +1 more source

CREATING TIME: LONG TERM ON THE SHORT TERM

Text from a blog post on helping students make time for professional development, even when it is busy- and practicing what you preach. On graduation, veterinarians (and the rest of us) are never "done" with work; there is *always* more work to do.
openaire   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Other title: Long Term Care

application/pdfA set of 5 documents provided by the Office of the Kansas Long Term Care Ombudsman, with resources and information on Long Term Care.Kansas Office of the State Long-Term Care Ombudsman -- Kansas Office of the State Long-Term Care Ombudsman
Kansas. Long Term Care Ombudsman.
core   +1 more source

Identification of an unknown source term for a time fractional fourth-order parabolic equation

Electronic Journal of Differential Equations, 2016
In this article, we considered two inverse source problems for fourth-order parabolic differential equation with fractional derivative in time. Determination of a space dependent source term from the data given at some time t=T is considered in one ...
Sara Aziz, Salman A. Malik
doaj  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Long-term time-series pollution forecast using statistical and deep learning methods. [PDF]

Neural Comput Appl, 2021
Nath P, Saha P, Middya AI, Roy S.
europepmc   +1 more source