Results 211 to 220 of about 79,351 (276)

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

CHALLENGES AND THREATS TO THE ACTIVITIES OF BANK INSTITUTIONS OF UKRAINE – REORGANIZATION, TERMINATION, LIQUIDATION

Scientific opinion: Economics and Management, 2019
openaire   +1 more source

Policy Capacity for Novel Technology Adoption: Developmental Insights From Singapore's AI Adoption in Long‐Term Care

Public Administration and Development, EarlyView.
ABSTRACT Worldwide, artificial intelligence‐driven technologies, including robotics and autonomous systems (RAS), are adopted to address manpower shortages in long‐term care. However, their effective use requires a reasonable degree of policy capacity across individual‐, organisational‐ and system‐levels.
Si Ying Tan, Lili Li, Araz Taeihagh
wiley   +1 more source

Inflammatory pathways in transfusion-associated circulatory overload. [PDF]

Blood Vessel Thromb Hemost
Vik RE, Bulle EB, Webley WC, Visintainer P, Ramirez S, St Marie P, Stec T, O'Hearn L, Andrzejewski C, Vlaar APJ.   +9 more
europepmc   +1 more source

Integrative Modeling in the Age of Machine Learning: A Summary of HADDOCK Strategies in CAPRI Rounds 47–55

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The HADDOCK team participated in CAPRI rounds 47–55 as server, manual predictor, and scorers. Throughout these CAPRI rounds, we used a plethora of computational strategies to predict the structure of protein complexes. Of the 10 targets comprising 24 interfaces, we achieved acceptable or better models for 3 targets in the human category and 1 ...
Victor Reys, Marco Giulini, Vlad Cojocaru, Anna Engel, Xiaotong Xu, Jorge Roel‐Touris, Cunliang Geng, Francesco Ambrosetti, Brian Jiménez‐García, Zuzana Jandova, Panagiotis I. Koukos, Charlotte van Noort, João M. C. Teixeira, Siri C. van Keulen, Manon Réau, Rodrigo V. Honorato, Alexandre M. J. J. Bonvin   +16 more
wiley   +1 more source

Microbiological risk assessment during the procurement and processing of cells, tissues and breast milk using the MiRCA tool. [PDF]

Sci Rep
Jandová M, Rudolfová Š, Švorcová M, Měřička P.   +3 more
europepmc   +1 more source

Structure and Mechanism of PhdC, a Prenylated‐Flavin Maturase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Dominic R. Whittall, Henry G. Box, Karl A. P. Payne, Stephen A. Marshall, David Leys   +4 more
wiley   +1 more source

Development and validation of cryopreserved or freeze-dried decellularized human dermis for transplantation. [PDF]

Cell Tissue Bank
Montagner G, Barbazza A, Pant M, Lugas AT, Serino G, Bignardi C, Terzini M, Vantini A, Stefanelli J, Trojan D.   +9 more
europepmc   +1 more source

An enhanced multidimensional requirement oriented quality function deployment method for sustainable self service machine design. [PDF]

Sci Rep
Zhu L, Husin MH.
europepmc   +1 more source

Aptamer-based approaches in leukemia: a paradigm shift in targeted therapy. [PDF]

Clin Exp Med
Bayani A, Abosaoda MK, Rizaev J, Nazari M, Jafari Z, Soleimani Samarkhazan H.   +5 more
europepmc   +1 more source