Results 161 to 170 of about 725,409 (217)

Material‐Encoded Synchronization of Immunogenic Cell Death With Adenosine A2A Receptor Blockade Reprograms the Tumor Microenvironment

Advanced Science, Volume 13, Issue 52, 18 September 2026.
A bismuth–copper diselenide–based nanoplatform (BSCS@PHY) coordinates immunogenic cell death with local A2A receptor blockade in 4T1 tumors. Thermally triggered shell melting exposes catalytic surfaces for glutathione depletion and chemodynamic ROS generation, while co‐delivering an A2AR antagonist and yeast‐wall adjuvant to enhance dendritic‐cell ...
Xiangting Yi, Hanlou Yang, Junting Huang, Pengfei Wu, Shiying Zhou, Zunde Liao, Min Han, Zishan Chen, Xiaoyu Huang, Nan Ma, Jie Zhou, Mingqiang Li, Yiling Zhong   +12 more
wiley   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, Volume 13, Issue 53, 24 September 2026.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source

Dual‐Acceptor Engineered Multimodal Phototheranostic NIR‐II AIEgens for Orthotopic Breast Cancer Treatment

Aggregate, Volume 7, Issue 9, September 2026.
A robust NIR‐II AIE small molecule with multimodal phototheranostic features was rationally constructed through a dual‐acceptor engineering strategy, which enables exceptional NIR‐II fluorescence–photoacoustic–photothermal trimodal imaging and synergistic photodynamic–photothermal therapy in a mouse orthotopic breast cancer model under 808 nm laser ...
Miaomiao Kang, Yu Pei, Zengming Yang, Yinzhen Pan, Zhijun Zhang, Xue Li, Dong Wang, Ben Zhong Tang   +7 more
wiley   +1 more source

Rationally Designed AIE Small Molecule Enabling NIR‑II Absorption and Multimodal Phototheranostics for Orthotopic Colon Cancer Treatment

Aggregate, Volume 7, Issue 9, September 2026.
An NIR‑II‑absorbing “one‑for‑all” multimodal phototheranostic AIEgen, rationally designed via synergistic π‑bridge–acceptor planarization, bond vibration incorporation, and alkyl chain engineering, enables exceptional 1064 nm‑excitable trimodal fluorescence–photoacoustic–photothermal (FLI–PAI–PTI) imaging and synergistic photodynamic–photothermal (PDT ...
Miaomiao Kang, Zengming Yang, Jun Zhu, Hao Yang, Shuaiyin Zhang, Zhijun Zhang, Xue Li, Dong Wang, Ben Zhong Tang   +8 more
wiley   +1 more source

Spatial Cell Death and Oxidative Stress Dynamics in Gas Plasma‐Treated Tumor Tissues

Advanced NanoBiomed Research, Volume 6, Issue 9, September 2026.
Schematic representation of the four experimental models to study tissue penetration and oxidation. Four tissue models were used. Human pancreatic cancer cells were grown on the chorioallantois membrane of chicken embryos and gas plasma‐treated in ovo, murine colorectal tumor tissue was gas plasma‐exposed ex vivo, murine squamous cell carcinoma cells ...
Anke Schmidt, Shahrzad Rokhsary, Linus Hübner, Lea Miebach, Sander Bekeschus   +4 more
wiley   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, Volume 4, Issue 3, September 2026.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Real time in vivo efficacy monitoring of desialylation and perforation enhanced immunotherapy of cancer

BMEMat, Volume 4, Issue 3, September 2026.
A multifunctional nanomedicine is designed to engineer NK cells for enhanced cancer immunotherapy through perforation and desialylation, enabling real‐time monitoring of ATP and GrB levels for precise efficacy assessment. Abstract Efficient enhanced NK cell therapy is of critical importance in the immune treatment of cancer.
Yuanjiao Yang, Yuru Wang, Xuemei Li, Chaoyi Yang, Yuhui Yang, Yanyun Fang, Lin Ding, Yunlong Chen, Huangxian Ju   +8 more
wiley   +1 more source

Plasma exosomal miR‐339‐3p promotes myocardial remodeling in chronic heart failure by regulating USP25‐mediated DDX58 deubiquitination

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
In the patients of chronic heart failure (HF), miR‐339‐3p derived from plasma exosomes can target ubiquitin‐specific protease 25, inhibiting its K48‐linked deubiquitination modification of DDX58, leading to increased ubiquitination and degradation of DDX58.
Guoqiang Jing, Ting Xu, Yuhong Ma
wiley   +1 more source

Prevotella loescheii attenuates pregnancy‐induced hypertension by reshaping placental immunity and halting macrophage pyroptosis

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Prevotella loescheii alleviates pregnancy‐induced hypertension (PIH) by reshaping the placental immune microenvironment, suppressing oxidative stress (OS)‐mediated NLRP3 pyroptosis, and restoring short‐chain fatty acid (SCFA) metabolic homeostasis. P. loescheii alleviates PIH by reshaping the placental immune microenvironment, suppressing OS‐mediated ...
Jingjing Wu, Linlin Hu, Peipei Chen, Lihong Cai   +3 more
wiley   +1 more source

Deltex 2 Mediates Oxidative Stress and Neurotoxicity in Freezing of Gait of Parkinson's Disease via the Notch2‐Nrf2 Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Under normal conditions, Notch2 promotes Nrf2 transcription by forming a transcriptional activation complex, which is crucial for maintaining the antioxidant capacity of human dopamine‐like neural cells. In pathological conditions, increased DTX2 expression has been shown to mediate Notch2 ubiquitination and subsequent degradation, leading to reduced ...
Qibin Zheng, Xiaohua Zheng, Junxin Zhao, Lin Lin, Yibiao Chen, Huiqing Wang, Zhangya Lin, Lianghong Yu   +7 more
wiley   +1 more source