Results 171 to 180 of about 725,409 (217)

Cancer cell‐selective ectopic expression of CD20 as an antigen enables rituximab repurposing for solid tumour immunotherapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
A recombinant AAV delivered tumour gene therapy. NF‐κB drives tumour‐selective antigen (e.g., CD20) expression. Ectopic CD20 enables rituximab repurposing to solid tumours. ADCC, ADCP, and CDC contribute to the antitumour activity. Abstract Background Despite the clinical success of cancer immunotherapies, their efficacy is often compromised by antigen‐
Ziyan Kong, Yile Wang, Yunqi Zhao, Lu Wang, Zhimin Fan, Yongqian Shu, Jinke Wang   +6 more
wiley   +1 more source

Fucoxanthin Attenuates Hepatic Damage in a d‐Galactose‐Induced Accelerated Aging Mouse Model: Insight Into Underlying Mechanisms

Food Frontiers, Volume 7, Issue 5, September 2026.
Fucoxanthin alleviates d‐galactose‐induced hepatic damage by reducing oxidative stress, inflammation, and multiple programmed cell death pathways. ABSTRACT The global population is aging rapidly, and aging‐related hepatic damage poses a significant public health challenge.
Han‐Ni Wei, Cheng‐Yu Yang, Hui Li, Shi‐Xiang Wu, Qing‐Yan Zou, Yan Zheng, Kazuo Miyashita, Yu‐Hong Yang, Lei Du   +8 more
wiley   +1 more source

Breast implant-associated diffuse large cell B-cell lymphoma (BIA-DLBCL) - a case report and a treatment algorithm. [PDF]

JPRAS Open
Borgolte MB, Sokolow AJ, Bittner MA, Schreml S, Klapper W, von Fritschen U, Schiltz D.   +6 more
europepmc   +1 more source

TSG From Polygonum multiflorum Thunb. Attenuates Experimental Premature Ovarian Insufficiency in Association With Reduced ZBP1/PANoptosis Signaling

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
This study shows that TSG, the major bioactive constituent of Polygonum multiflorum Thunb., ameliorates POI in association with suppression of ZBP1‐driven PANoptosis. In a POI rat model, TSG restored estrous cyclicity, improved hormone profiles, and preserved follicular reserve.
Jinhong Li, Tiao Xie, Chang Lin, Danhong Peng, Qin Shi, Can Zhu   +5 more
wiley   +1 more source

T-lymphoblastic leukemia/lymphoma: a comprehensive review of pathology, molecular features, and differential diagnosis. [PDF]

J Pathol Transl Med
Danielson D, Lagerstrom IT, Rogers M, Simon K, Aguilera NS, Auerbach A.   +5 more
europepmc   +1 more source

Gut Microbiota Dysbiosis Mediates 125I‐Induced Radiation Colitis via Host Transcriptional Regulation

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Background Iodine‐125 (125I) seed therapy is recognized for treating abdominal solid tumors with minimal adjacent tissue damage but may induce radiation colitis when its implantation near colonic tissues, leading to a poor prognosis. Nevertheless, the underlying pathogenesis is not well understood.
Pingping Liu, Xiong Zeng, Wenjing Liu, Huichao Xie, Yongkun Fang, Erwan Yang, Xiaoqi Tang, Chenglin Fan, Yihui Chen   +8 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation. [PDF]

Mol Oncol
Xenou L, Tzenaki N, Tsapara A, Tzardi M, Papakonstanti EA.   +4 more
europepmc   +1 more source

Icariside II in Neurological Disorders: Mechanistic Insights Into Alzheimer's Disease, Cerebral Ischemia and Parkinson's Disease

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The graphical abstract represents the underlying neuroprotective potential of ICS II against Alzheimer's disease, Cerebral ischemia and Parkinson disease. ICS II downregulates ROS production, inflammation, mitochondrial dysfunction and apoptosis along with regulating their key signalling pathways.
Ashutosh Solanki, Khushi Sharma, Jagrati Jain, Niraj Kumar Singh, Praveen T. Krishnamurthy   +4 more
wiley   +1 more source

ALY688 Protects Against Myocardial Ischemia‐Reperfusion Injury via Direct Effects and Rab8a‐Dependent Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
This study identifies ALY688, a synthetic adiponectin receptor agonist, as a potent cardioprotective agent against ischemia‐reperfusion injury. ALY688 reduced infarct size, cardiomyocyte death, and oxidative stress, while preserving cardiac function. Mechanistically, it enhanced extracellular vesicle (EV) number through Rab8a‐dependent signaling and ...
Hye Kyoung Sung, Jialing Tang, Yubin Lei, Khang Nguyen, Eddie Tam, Jun Wu, Ren‐Ke Li, Vincent Richard, Christoph H. Borchers, Lina Antounians, Dylan Burger, Augusto Zani, Gary Sweeney   +12 more
wiley   +1 more source