Results 11 to 20 of about 725,409 (217)

Enhancing Terminal Deoxynucleotidyl Transferase Activity on Substrates with 3′ Terminal Structures for Enzymatic De Novo DNA Synthesis [PDF]

Genes, 2020
Enzymatic oligonucleotide synthesis methods based on the template-independent polymerase terminal deoxynucleotidyl transferase (TdT) promise to enable the de novo synthesis of long oligonucleotides under mild, aqueous conditions.
Daniel Arlow, Sebastian Barthel, Jesus F Barajas   +2 more
exaly   +6 more sources

Modified Nucleotides as Substrates of Terminal Deoxynucleotidyl Transferase [PDF]

Molecules, 2017
The synthesis of novel modified nucleotides and their incorporation into DNA sequences opens many possibilities to change the chemical properties of oligonucleotides (ONs), and, therefore, broaden the field of practical applications of modified DNA.
Jevgenija Jakubovska, Rolandas Meškys, Maksim Bratchikov   +2 more
exaly   +4 more sources

Usefulness of Terminal Deoxynucleotidyl Transferase as Prognosticator in Leukemia Patients

The International Journal of Biological Markers, 1993
Peripheral blood samples from 55 previously untreated leukemia patients (33 males, 22 females) were analysed for terminal deoxynucleotidyl transferase (TdT) activity.
J.M. Bhatavdekar, S.N. Trivedi, H.H. Vora, S.N. Shukla   +3 more
doaj   +2 more sources

Cutaneous T-Cell Acute Lymphoblastic Leukemia and the Expression Pattern of Terminal Deoxynucleotidyl Transferase Immunostaining in Mycosis Fungoides and Spongiotic Dermatitis [PDF]

Dermatopathology, 2019
Background/Aims: T-cell acute lymphoblastic leukemia (T-ALL) is an uncommon, aggressive malignancy that rarely presents in the skin and is generally not considered as part of the differential diagnosis by dermatologists and dermatopathologists.
Joshua J. Clark, Jason E. Hawkes, Scott R. Florell, Rodney R. Miles, David A. Wada   +4 more
doaj   +2 more sources

Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants

, 1996
We show through sequence analysis of rearranged immunoglobulin variable (Ig-V) region genes from memory B cells of mouse mutants generated by gene targeting that terminal deoxynucleotidyl transferase, CD23, interleukin-4, IgD and CD30 are dispensable for
Müller, Werner, Gilfillan, S., Susan Gilfillan, Meiering, M., Mathis, Diane, Kikutani, H., Myriam Meiering, Gemma Texidó, Jacobs, Heinz, Mathis, D., Texidó, G., Rajewsky, K., Christophe Benoist, Fujiwara, H., Jürgen Roes, Diane Mathis, Müller, Werner; id_orcid, Texidó, Gemma, Kikutani, Hitoshi, Meiering, Myriam, Hitoshi Kikutani, Ryuichi Amakawa, Tak W. Mak, Nobuaki Yoshida, Roes, Jürgen, Kühn, R., Roes, J., Mak, Tak W., Kishimoto, Tadamitsu, Hiroshi Fujiwara, Jacobs, H., Kishimoto, T., Ralf Kühn, Kühn, Ralf, Mak, T.W., Yoshida, N., Amakawa, R., Gilfillan, Susan, Werner Müller, Heinz Jacobs, Rajewsky, Klaus, Yoshida, Nobuaki, Müller, W., Klaus Rajewsky, Benoist, Christophe, Fujiwara, Hiroshi, Amakawa, Ryuichi, Benoist, C., Tadamitsu Kishimoto   +48 more
core   +12 more sources

Terminal deoxynucleotidyl transferase-mediated formation of protein binding polynucleotides. [PDF]

Nucleic Acids Res, 2021
Terminal deoxynucleotidyl transferase (TdT) enzyme plays an integral part in the V(D)J recombination, allowing for the huge diversity in expression of immunoglobulins and T-cell receptors within lymphocytes, through their unique ability to incorporate ...
Ashley J, Schaap-Johansen AL, Mohammadniaei M, Naseri M, Marcatili P, Prado M, Sun Y.   +6 more
europepmc   +3 more sources

Terminal deoxynucleotidyl transferase‐positive high‐grade B‐cell lymphoma with MYC and BCL2 rearrangements transformed from follicular lymphoma [PDF]

eJHaem
Radu Chiriac, Lucile Baseggio, Marie Donzel   +2 more
doaj   +2 more sources

Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase. [PDF]

Biochim Biophys Acta, 2010
Nearly every DNA polymerase characterized to date exclusively catalyzes the incorporation of mononucleotides into a growing primer using a DNA or RNA template as a guide to direct each incorporation event.
Motea EA, Berdis AJ.
europepmc   +2 more sources

Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors

Polish Journal of Pathology, 2022
Terminal deoxynucleotidyl transferase (TdT) is a unique type of DNA polymerase predominantly expressed in precursor lymphoid cells and acute lymphoblastic leukemia.
Rafał Pęksa, Michał Kunc, Michał Bieńkowski, Marta Popęda, Wojciech Biernat   +4 more
doaj   +1 more source

A case of conjunctival precursor T cell lymphoblastic lymphoma presenting with salmon colored conjunctival mass

American Journal of Ophthalmology Case Reports, 2022
Purpose: T-Lymphoblastic lymphoma (T-LBL) is a rare malignant tumor originated from precursor T-lymphocytes that differentiate to T lymphocytes. We report a rare case of T-LBL presenting with conjunctival mass as the first sign.
Risa Sugawara, Yoshihiko Usui, Reisuke Takahashi, Toshitaka Nagao, Hiroshi Goto   +4 more
doaj   +1 more source