Results 21 to 30 of about 725,409 (217)

Microarray detection method for pathogen genes by on-chip signal amplification using terminal deoxynucleotidyl transferase

Micro and Nano Systems Letters, 2022
A microarray detection method based on on-chip signal amplification using terminal deoxynucleotidyl transferase (TdT) was developed to visualize pathogenic genes.
Tai-Yong Kim, Min-Cheol Lim, Jeong-A Lim, Sung-Wook Choi, Min-Ah Woo   +4 more
doaj   +1 more source

Occurrence of a Terminal Deoxynucleotidyl Transferase-Like Activity in N-2-Fluorenylacetamide-treated Rat Liver [PDF]

, 1985
1985-01A new enzyme activity that resembles terminal deoxynucleotidyl transferase (TdT-like activity) was found in rat liver. Upon treatment of rats with a hepatocarcinogen, N-2-fluorenylacetamide, the TdT-like activity increased in parallel with DNA ...
KOJIMA, KIYOHIDE, YOSHIDA, SHONEN, NAKAMURA, HIROMU   +2 more
core   +1 more source

Measurement of DNA damage by terminal deoxynucleotidyl transferase reaction [PDF]

, 2012
An improved terminal deoxynucleotidyl transferase- mediated dUTP-biotin nick end labeling method for the quantification of DNA damage in tissues and cultured cells was developed.
Miyajima, Miki, Saito, Takeshi, Komori, Miyako, Hosokawa, Toshiyuki, Kurasaki, Masaaki, Sun, Yongkun   +5 more
core   +1 more source

TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE DEVELOPMENT IN THE POSTNATAL HUMAN THYMUS [PDF]

, 1980
Terminal deoxynucleotidyl transferase activity was studied in 42 whole human thymuses of different ages (2 days to 70 years). The results indicate that enzyme activity is high perinatally, falls soon after birth, rises to maximal activity early in life ...
Kiefer, Carol A, Frank L Meyskens, James F Jones, Jones, James F, Carol A Kiefer, Meyskens, Frank L   +5 more
core   +1 more source

Modification of 3’ Terminal Ends of DNA and RNA Using DNA Polymerase θ Terminal Transferase Activity

Bio-Protocol, 2017
DNA polymerase θ (Polθ) is a promiscuous enzyme that is essential for the error-prone DNA double-strand break (DSB) repair pathway called alternative end-joining (alt-EJ). During this form of DSB repair, Polθ performs terminal transferase activity at the
Trung Hoang, Tatiana Kent, Richard Pomerantz   +2 more
doaj   +1 more source

Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining

eLife, 2016
DNA polymerase θ (Polθ) promotes insertion mutations during alternative end-joining (alt-EJ) by an unknown mechanism. Here, we discover that mammalian Polθ transfers nucleotides to the 3’ terminus of DNA during alt-EJ in vitro and in vivo by oscillating ...
Tatiana Kent, Pedro A Mateos-Gomez, Agnel Sfeir, Richard T Pomerantz   +3 more
doaj   +1 more source

Diagnostic Utility of TUNEL Staining for Degenerative Keratoacanthoma Requiring Pathologic Differentiation from Seborrheic Keratosis

Case Reports in Dermatology, 2023
Tumors developed in 2 old women presented with pathological findings similar to seborrheic keratosis, although the clinical feature of tumor showed typical keratoacanthoma.
Mari Nakanishi, Makoto Kondo, Koji Habe, Akinobu Hayashi, Keiichi Yamanaka   +4 more
doaj   +1 more source

Effects of Exosomes on Neurological Function Recovery for Ischemic Stroke in Pre-clinical Studies: A Meta-analysis

Frontiers in Cellular Neuroscience, 2020
Background: Exosomes, especially stem cell-derived exosomes, have been widely studied in pre-clinical research of ischemic stroke. However, their pooled effects remain inconclusive.Methods: Relevant literature concerning the effects of exosomes on ...
Mudan Huang, Zhongqiu Hong, Chongjun Xiao, Lili Li, Lilin Chen, Shimei Cheng, Tingting Lei, Haiqing Zheng   +7 more
doaj   +1 more source

EFFICACY OF TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE (TDT) AS A DIAGNOSTIC MARKER IN ACUTE LYMPHOBLASTIC LEUKEMIA

, 2020
Aim: To differentiate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia and to Isolate Terminal deoxynucleotidyl transferase positive blasts in CSF. Place and Duration: In the Oncology department of Mayo Hospital Lahore for one-year duration from
1Dr Nouman Shafique, 2Dr Muhammad Tehseen Ali, 3Dr Farhan Ghaffar Bhatti
core   +1 more source

Intramyocardial injection of hypoxia-conditioned extracellular vesicles modulates apoptotic signaling in chronically ischemic myocardiumCentral MessagePerspective

JTCVS Open, 2023
Objective: Limited treatments exist for nonoperative chronic coronary artery disease. Previously, our laboratory has investigated extracellular vesicle (EV) therapy as a potential treatment for chronic coronary artery disease using a swine model and ...
Dwight D. Harris, MD, Sharif A. Sabe, MD, Mohamed Sabra, MD, Cynthia M. Xu, MD, Akshay Malhotra, Mark Broadwin, MD, Debolina Banerjee, MD, M. Ruhul Abid, MD, PhD, Frank W. Sellke, MD   +8 more
doaj   +1 more source