Results 51 to 60 of about 814,394 (309)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

End-of-life care ethical decision-making: Shiite scholars' views.

Journal of Medical Ethics and History of Medicine, 2015
Recent advances in life-sustaining treatments and technologies, have given rise to newly-emerged, critical and sometimes, controversial questions regarding different aspects of end-of-life decision-making and care.
Mina Mobasher, Kiarash Aramesh, Farzaneh Zahedi, Nouzar Nakhaee, Mamak Tahmasebi, Bagher Larijani   +5 more
doaj  

Realizing the Wishes of Terminal Patients: Caregiving Transport Efforts for End of Life in the Kuji Area of Japan

Palliative Medicine Reports, 2021
Background: There are some restrictions in Japan regarding end-of-life care. For example, only physicians can legally issue death certificates.
Mizunori Yaegashi, Koki Otsuka, Kasumi Nitta, Chihiro Tono, Yukihiro Minagawa, Toru Yoshida, Hidenobu Kawamura   +6 more
doaj   +1 more source

Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability. [PDF]

, 2019
HIV-1 Rev is an essential viral regulatory protein that facilitates the nuclear export of intron-containing viral mRNAs. It is organized into structured, functionally well-characterized motifs joined by less understood linker regions.
Fernandes, Jason D, Frankel, Alan D, Jayaraman, Bhargavi, Smith, Cynthia, Yang, Shumin   +4 more
core   +3 more sources

Terminating a Patient-Physician Relationship

AMA Journal of Ethics, 2001
An ethical case about terminating a physician-patient relationship arises when an obstetrician decides to refer a young, pregnant patient who is abusing alcohol early in her pregnancy to a colleague who is not as busy. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts

Neurobiology of Disease, 2005
Accumulation of mutant Huntingtin (Htt), especially the N-terminal-cleaved Htt, participates in the pathophysiology of Huntington's disease (HD). It is difficult to elucidate temporal properties of the translocation of “endogenous” Htt using autopsy HD ...
Akira Sawa, Eiichiro Nagata, Siobhan Sutcliffe, Pratima Dulloor, Matthew B. Cascio, Yuji Ozeki, Sophie Roy, Christopher A. Ross, Solomon H. Snyder   +8 more
doaj   +1 more source

Pharmacist’s Intervention Considering the Prognosis for a Terminal Cancer Patient: A Case Report

Pharmacy, 2020
Prognostic prediction has been reported to affect the decision of doctors and non-physician health care providers such as nurses, social workers, pastors, and hospice volunteers on the selection of appropriate medical interventions.
Masahiro Okada, Kazuko Okazaki, Keisuke Kimura, Hiroki Sugihara, Fumiyoshi Murakami, Shinya Okamoto, Yoshinori Hoshino, Yuka Goto, Kengo Banshoya, Tadashi Onoda, Eisuke Takei, Shuso Takeda, Narumi Sugihara   +12 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

From terminal ileum to terminal diagnosis: The critical role of terminal ileum intubation in diagnosing langerhans cell histiocytosis in a patient with TAR syndrome

Radiology Case Reports
The co-occurrence of Thrombocytopenia with Absent Radius (TAR) syndrome and Langerhans Cell Histiocytosis (LCH) is exceedingly rare, with scant documentation in existing medical literature.
Mena Louis, DO, Chad Copper, MD, Elaine Lelli, MD, Joseph Conway, MD, Daniel Sarmiento, MD, Hardeep Singh, PhD   +5 more
doaj   +1 more source