Results 31 to 40 of about 438,461 (269)
Associations between Sleep Disorders and Comfort at End-of-Life: Opportunities for Improvement [PDF]
Sleep Medicine Research, 2018 Comfort and quality of life (QoL) at the end-of-life (EOL) comprise physical and psychosocial domains. The effects of sleep disorders such as insomnia on comfort-related factors have been widely reported for cancer patients, yet the effect of sleep ...
Karen J Klingman, Suzanne Sullivan
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
A Terminal Patient’s Hopes for Connections Transcending Time
Anthropology & Aging, 2012 Terminal cancer patients face not only issues unique to their diseases, but also issues rooted in their previous life experiences, including physical, social, psychological, and spiritual pain.
Megumi Kondo-Arita
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Palliative Medicine Reports, 2021 Background: There are some restrictions in Japan regarding end-of-life care. For example, only physicians can legally issue death certificates.
Mizunori Yaegashi +6 more
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
End-of-life care ethical decision-making: Shiite scholars' views.
Journal of Medical Ethics and History of Medicine, 2015 Recent advances in life-sustaining treatments and technologies, have given rise to newly-emerged, critical and sometimes, controversial questions regarding different aspects of end-of-life decision-making and care.
Mina Mobasher +5 more
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Neurobiology of Disease, 2005 Accumulation of mutant Huntingtin (Htt), especially the N-terminal-cleaved Htt, participates in the pathophysiology of Huntington's disease (HD). It is difficult to elucidate temporal properties of the translocation of “endogenous” Htt using autopsy HD ...
Akira Sawa +8 more
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Pharmacist’s Intervention Considering the Prognosis for a Terminal Cancer Patient: A Case Report
Pharmacy, 2020 Prognostic prediction has been reported to affect the decision of doctors and non-physician health care providers such as nurses, social workers, pastors, and hospice volunteers on the selection of appropriate medical interventions.
Masahiro Okada +12 more
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FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source