Results 41 to 50 of about 438,461 (269)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

From terminal ileum to terminal diagnosis: The critical role of terminal ileum intubation in diagnosing langerhans cell histiocytosis in a patient with TAR syndrome

Radiology Case Reports
The co-occurrence of Thrombocytopenia with Absent Radius (TAR) syndrome and Langerhans Cell Histiocytosis (LCH) is exceedingly rare, with scant documentation in existing medical literature.
Mena Louis, DO, Chad Copper, MD, Elaine Lelli, MD, Joseph Conway, MD, Daniel Sarmiento, MD, Hardeep Singh, PhD   +5 more
doaj   +1 more source

O Paciente Terminal, o Médico e o Medo de Morrer / The Terminal Patient, the Doctor and the Fear of Dying

Revista Ciências em Saúde, 2012
Desde a minha adolescência, eu sempre lia os livros escritos pelos médicos que versavam sobre as suas vivências no dia a dia da profissão, eu os admirava pelo elevado teor humano que emanava de seus escritos.
Marco Tullio de Assis Figueiredo
doaj   +1 more source

Hope in Hospitalized Patients with Terminal Cancer [PDF]

International Journal of Environmental Research and Public Health, 2019
Hope is of great importance for patients diagnosed with cancer, especially those that are terminally ill. The diagnosis often puts an end to the realization of personal, social, and professional goals. The aim of this study was to characterize the hope of hospitalized patients diagnosed with cancer in the terminal phase of the disease.
Bożena Baczewska, Bogusław Block, Beata Kropornicka, Antoni Niedzielski, Maria Malm, Agnieszka Zwolak, Marta Makara-Studzińska   +6 more
openaire   +3 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

La calidad de vida en la fase terminal Life quality for the terminal patient

Iatreia, 1994
<p class="MsoNormal"><span style="font-size: 9pt; font-family: Arial">Se define al paciente tem1inal desde los puntos de vista terapéutico y biológico y se explica cómo el concepto de calidad de vida se puede aplicar a dicho paciente para ...
Oscar Velásquez Acosta
doaj  

’n Pastorale ontsluiting van Johannes 11: ’n begeleidingsnarratief

In die Skriflig, 2006
A pastoral interpretation of John 11: a guidance narrative A biblical narrative can provide guidelines to the terminal patient on his/her journey of life.
J. Steyn
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Internação domiciliar do paciente terminal: o olhar do cuidador familiar Internación domiciliaria del paciente terminal: la visión del cuidador familiar Terminal patient home care: the family caregiver's perspective

Revista Gaúcha de Enfermagem, 2012
O presente estudo buscou conhecer as relações entre paciente, cuidadores familiares e equipe de saúde, na internação domiciliar, sob o olhar do cuidador familiar.
Stefanie Griebeler Oliveira, Alberto Manuel Quintana, Maria de Lourdes Denardin-Budó, Natália de Andrade de Moraes, Manoela Fonseca Lüdtke, Paula Argemi Cassel   +5 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source