Results 51 to 60 of about 438,461 (269)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Terminating a Patient-Physician Relationship
AMA Journal of Ethics, 2001 An ethical case about terminating a physician-patient relationship arises when an obstetrician decides to refer a young, pregnant patient who is abusing alcohol early in her pregnancy to a colleague who is not as busy. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Acta Médica Costarricense, 2011 El manejo adecuado de síntomas en pacientes terminales permite a los pacientes y a sus seres queridos el espacio para resolver asuntos emocionales, psicológicos y espirituales.
Gabriel Carvajal-Valdy +2 more
doaj
THE CLINICAL ROLES OF PSYCHOLOGISTS IN END-OF-LIFE CARE: A NEW HORIZON IN INDIAN PALLIATIVE CARE
The Anatolian Journal of Family Medicine, 2018 Among all the various existing skills needed in palliative end-of-life care, none is more important the ability to communicate effectively. Terminal ill experience is the time when patients were overwhelmed with several emotional and psychological ...
Vaiphei Suantak Demkhosei +1 more
doaj +1 more source
Antimicrobial Resistance and Infection Control, 2020 Background Inadequate hospital cleaning may contribute to cross-transmission of pathogens. It is important to implement effective cleaning for the safe hospital environment.
I-Chen Hung +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source