Results 61 to 70 of about 807,861 (314)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

End-of-life care and dementia [PDF]

, 2006
In the UK, research continues to confirm that people with certain chronic illnesses, such as chronic lung disease and cardiac failure, represent the ‘disadvantaged dying’ compared to those with terminal cancer.
Ballard, Clive, Daley, Sarah, Hughes, Julian, Keady, John, Robinson, Louise, Volicer, Ladislav   +5 more
core   +1 more source

La calidad de vida en la fase terminal Life quality for the terminal patient

Iatreia, 1994
<p class="MsoNormal"><span style="font-size: 9pt; font-family: Arial">Se define al paciente tem1inal desde los puntos de vista terapéutico y biológico y se explica cómo el concepto de calidad de vida se puede aplicar a dicho paciente para ...
Oscar Velásquez Acosta
doaj  

O Paciente Terminal, o Médico e o Medo de Morrer / The Terminal Patient, the Doctor and the Fear of Dying

Revista Ciências em Saúde, 2012
Desde a minha adolescência, eu sempre lia os livros escritos pelos médicos que versavam sobre as suas vivências no dia a dia da profissão, eu os admirava pelo elevado teor humano que emanava de seus escritos.
Marco Tullio de Assis Figueiredo
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Pediatric Kennedy Terminal Ulcer [PDF]

, 1999
Photograph of Fossett's circus loads, 2 AEC Matadors - KKN412 - and trailers, taken Forest site, 28 September 1959 whole side ...
Reitz, Megan, Schindler, Christine A.
core   +1 more source

Serotyping of Toxoplasma gondii Infection Using Peptide Membrane Arrays. [PDF]

, 2019
The intracellular parasite Toxoplasma gondii can cause chronic infections in most warm-blooded animals, including humans. In the USA, strains belonging to four different Toxoplasma clonal lineages (types 1, 2, 3, and 12) are commonly isolated, whereas ...
Arranz-Solís, David, Commodaro, Alessandra G, Cordeiro, Cynthia, Dardé, Marie Laure, Grigg, Michael E, Saeij, Jeroen PJ, Young, Lucy H   +6 more
core   +1 more source

Internação domiciliar do paciente terminal: o olhar do cuidador familiar Internación domiciliaria del paciente terminal: la visión del cuidador familiar Terminal patient home care: the family caregiver's perspective

Revista Gaúcha de Enfermagem, 2012
O presente estudo buscou conhecer as relações entre paciente, cuidadores familiares e equipe de saúde, na internação domiciliar, sob o olhar do cuidador familiar.
Stefanie Griebeler Oliveira, Alberto Manuel Quintana, Maria de Lourdes Denardin-Budó, Natália de Andrade de Moraes, Manoela Fonseca Lüdtke, Paula Argemi Cassel   +5 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source