Results 91 to 100 of about 842,336 (266)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Terminal value problems for first and second order nonlinear equations on time scales
Electronic Journal of Differential Equations, 2008 In this paper we examine "terminal" value problems for dynamic equations on time scales - that is, a dynamic equation whose solutions are asymptotic at infinity.
Christopher C. Tisdell, Roman Hilscher
doaj
A Dynamic Markov Reformulation of the Colonel Blotto Game Under Terminal Payoffs
MathematicsThe Colonel Blotto game is a classical model of competitive resource allocation, but equilibrium computation becomes difficult in heterogeneous and asymmetric instances.
Yuanyuan Zhang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
A Boundary Value Problem of Terminal Control with a Quadratic Criterion of Quality
Известия Иркутского государственного университета: Серия "Математика", 2014 In a Hilbert space, we consider the problem of terminal control with linear dynamics, fixed left end and moving right end of the trajectories. On the reachability set (under additional linear constraints) the objective functional as the sum of integral ...
A.S. Antipin, E.V. Khoroshilova
doaj
HeliyonWe report the fabrication of two terminal and three terminal gas sensor using Al-doped ZnO nanostructured-films and polymer electrolyte gate dielectric on glass substrate using vacuum free chemical method.
Raju Bhattarai +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source