Results 71 to 80 of about 15,760,783 (334)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structure and behaviour of the sperm terminal filament [PDF]

, 1982
Light- and electron-microscopic observations of Ciona and Lytechinus spermatozoa show a thin terminal filament at the distal end. The terminal filament is 5-6 microns long and contains the two central microtubules and a variable number of A-tubule ...
Brokaw, C. J., Omoto, C. K.
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A novel life-cycle analysis approach using pavement performance curves with cost and performance considerations

International Journal of Sustainable Engineering
The life-cycle duration (TLC) is typically assumed constant in pavement life-cycle analysis. The added scientific value of this paper is that (TLC) is considered a variable parameter to be estimated from the performance curve using a variable terminal ...
Khaled A. Abaza
doaj   +1 more source

A Class of Itô Diffusions with Known Terminal Value and Specified Optimal Barrier

Mathematics, 2020
In this paper, we study the optimal stopping-time problems related to a class of Itô diffusions, modeling for example an investment gain, for which the terminal value is a priori known.
Bernardo D’Auria, Alessandro Ferriero
doaj   +1 more source

Cube-Cut: Vertebral Body Segmentation in MRI-Data through Cubic-Shaped Divergences

, 2014
In this article, we present a graph-based method using a cubic template for volumetric segmentation of vertebrae in magnetic resonance imaging (MRI) acquisitions.
Egger, Jan, Freisleben, Bernd, Nimsky, Christopher, Schwarzenberg, Robert   +3 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Intentionally-underestimated value function at terminal state for temporal-difference learning with mis-designed reward

Results in Control and Optimization
Robot control using reinforcement learning has become popular, but its learning process often terminates midway through an episode for safety and time-saving reasons.
Taisuke Kobayashi
doaj   +1 more source

A Compound Controller Design for a Buck Converter

Energies, 2018
In order to improve the performance of the closed-loop Buck converter control system, a compound control scheme based on nonlinear disturbance observer (DO) and nonsingular terminal sliding mode (TSM) was developed to control the Buck converter.
Yueping Sun, Li Ma, Dean Zhao, Shihong Ding   +3 more
doaj   +1 more source

Terminal conditions as efficent instruments for numerical detection of the saddlepoint paths: a linear algebra non-robustness argument [PDF]

, 1993
In this paper, we address a criticism against the usual prescriptions on the introduction of terminal conditions as the principal numerical instruments for detecting the saddlepoint solutions of consistent expectations models. The argumentation is purely
Boucekkine, Raouf
core   +1 more source