Results 151 to 160 of about 1,648,060 (377)

Deciphering the Transcription Factor Landscape in Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation

Advanced Science, EarlyView.
The study deciphers the landscapes of lineage‐related transcription factors in prostatic adenocarcinoma and neuroendocrine prostate cancer using an innovative approach. These findings, validated across cohorts, highlight TFs' roles in cell development and offer novel therapeutic targets.
Yu Wang, Hui Xue, Xiaohui Zhu, Dong Lin, Zheng Chen, Xin Dong, Junru Chen, Mingchen Shi, Yuchao Ni, Jonathan Cao, Rebecca Wu, Connie Kang, Xinyao Pang, Francesco Crea, Yen‐Yi Lin, Colin C. Collins, Martin E. Gleave, Abhijit Parolia, Arul Chinnaiyan, Christopher J. Ong, Yuzhuo Wang   +20 more
wiley   +1 more source

State \u27Right to Try\u27 Acts: A Good Start, but a Federal Act Is Necessary [PDF]

, 2016
In an effort to help terminally ill patients bypass the FDA\u27s arduous, time-consuming approval process and have quicker access to potentially life-saving drugs, states across the country have passed right to try acts.
Black, Ellen A.
core   +1 more source

Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis

Advanced Science, EarlyView.
Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu, Li Zhang, Shengda Cao, Jingwen Zhang, Cheng Li, Yunlong Shan, Qiuping Liu, Zhexiong Yu, Qiaojun Fang, Yuhua Zhang, Xiaolong Fu, Kwok‐Fai So, Renjie Chai   +12 more
wiley   +1 more source

Difficulties in diagnosing and treating depression in the terminally ill cancer patient [PDF]

, 2000
Mari Lloyd‐Williams
openalex   +1 more source

Stereotyped Subclones Revealed by High‐Density Single‐Cell Lineage Tracing Support Robust Development

Advanced Science, EarlyView.
Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang, Zizhang Li, Jingyu Chen, Wenjing Yang, Xingxing He, Peng Wu, Feng Chen, Ziwei Zhou, Chenze Ren, Yuyan Shan, Xiewen Wen, Vassily A. Lyubetsky, Leonid Yu. Rusin, Xiaoshu Chen, Jian‐Rong Yang   +14 more
wiley   +1 more source

Convergence rates of Landweber-type methods for inverse problems in Banach spaces [PDF]

arXiv
Landweber-type methods are prominent for solving ill-posed inverse problems in Banach spaces and their convergence has been well-understood. However, how to derive their convergence rates remains a challenging open question. In this paper, we tackle the challenge of deriving convergence rates for Landweber-type methods applied to ill-posed inverse ...
arxiv  

Counseling Guidelines that Facilitate Acceptance of Death [PDF]

, 1977
Individuals who experience the death of a spouse, close friend or family member can receive counseling to faci1itate acceptance of death. A review of literature explains the stages the bereaved person will normally progress through.
Royse, James C.
core   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Subcutaneous Methadone in Terminally-Ill Patients [PDF]

, 2000
Matthew Makin, John S. Morley
openalex   +1 more source

NaBC1 Boron Transporter Enables Myoblast Response to Substrate Rigidity via Fibronectin‐Binding Integrins

Advanced Science, EarlyView.
Cells transduce the rigidity of the environment into biochemical cues through mechanotransductive cascades that modulate cell behavior. Here, a novel role for the boron transporter NaBC1 is identified as a mechanotransducer involved in regulating cell behavior via specific crosstalk with fibronectin‐binding integrins.
Juan Gonzalez‐Valdivieso, Giuseppe Ciccone, Udesh Dhawan, Tezz Quon, Eva Barcelona‐Estaje, Aleixandre Rodrigo‐Navarro, Rafael R. Castillo, Graeme Milligan, Patricia Rico, Manuel Salmeron‐Sanchez   +9 more
wiley   +1 more source