Results 61 to 70 of about 479,379 (269)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Yolculuğun Başlamasına veya Devamına Engel Olan Sebepler Yüzünden Navlun Sözleşmesinin Feshi
Anadolu Üniversitesi Hukuk Fakültesi DergisiSözleşme nazariyesi ve tatbikatında, bir sözleşmenin ifa ile sona ermesi ve tasfiyesi beklenir. Bununla birlikte bazı hâllerde, tarafların sözleşme ile bağlı kalmaları mümkün olmaz veya kendilerinden beklenemez.
Fevzi Fırat Gözüyeşil
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Cut, invariant rule, and loop-check free sequent calculus for PLTL
Lietuvos Matematikos Rinkinys, 2011 In this paper, some loop-check free saturation-like decision procedure is proposed for propositional linear temporal logic (PLTL) with temporal operators “next” and “always”.
Romas Alonderis +1 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Morbid Obesity: An Obstetric Challenge
Medical Journal of Dr. D.Y. Patil VidyapeethObesity, which has become a modern-day pandemic, is also compounding the problems of managing pregnant women. It affects the course of ante, intra and postpartum period of pregnancy.
Shabista Shaikh, Tanvi Nijhawan
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Social Work/Maatskaplike Werk, 2019 Studies on community engagement (CE) focus on its benefits but not enough on termination and difficulties experienced at the personal level with exiting projects.
Fluks, Lorenza Logan, Naidoo, Anthony V.
doaj +1 more source