Results 61 to 70 of about 1,419,974 (304)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Proving Termination Starting from the End

, 2013
We present a novel technique for proving program termination which introduces a new dimension of modularity. Existing techniques use the program to incrementally construct a termination proof. While the proof keeps changing, the program remains the same.
A. Podelski, A. Podelski, A.M. Ben-Amram, A.R. Bradley, B. Cook, B. Cook, B.A. Davey, C. Alias, D. Kroening, E. Albert, F.P. Ramsey, H.Y. Chen, M. Bozga, P. Cousot, S. Graf   +14 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Uniformity of Peptide Release Is Maintained by Methylation of Release Factors

Cell Reports, 2016
Termination of protein synthesis on the ribosome is catalyzed by release factors (RFs), which share a conserved glycine-glycine-glutamine (GGQ) motif.
William E. Pierson, Eric D. Hoffer, Hannah E. Keedy, Carrie L. Simms, Christine M. Dunham, Hani S. Zaher   +5 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Yolculuğun Başlamasına veya Devamına Engel Olan Sebepler Yüzünden Navlun Sözleşmesinin Feshi

Anadolu Üniversitesi Hukuk Fakültesi Dergisi
Sözleşme nazariyesi ve tatbikatında, bir sözleşmenin ifa ile sona ermesi ve tasfiyesi beklenir. Bununla birlikte bazı hâllerde, tarafların sözleşme ile bağlı kalmaları mümkün olmaz veya kendilerinden beklenemez.
Fevzi Fırat Gözüyeşil
doaj   +1 more source

Termination Analysis by Learning Terminating Programs [PDF]

, 2014
We present a novel approach to termination analysis. In a first step, the analysis uses a program as a black-box which exhibits only a finite set of sample traces. Each sample trace is infinite but can be represented by a finite lasso.
Heizmann, Matthias, Hoenicke, Jochen, Podelski, Andreas   +2 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Screen for rfaH Suppressors Reveals a Key Role for a Connector Region of Termination Factor Rho

mBio, 2017
RfaH activates horizontally acquired operons that encode lipopolysaccharide core components, pili, toxins, and capsules. Unlike its paralog NusG, which potentiates Rho-mediated silencing, RfaH strongly inhibits Rho.
Kuang Hu, Irina Artsimovitch
doaj   +1 more source

Functional Analysis of in Vivo and in Organello Footprinting of HeLa Cell Mitochondrial DNA in Relationship to ATP and Ethidium Bromide Effects on Transcription [PDF]

, 1997
In vivo and in organello footprinting techniques based on methylation interference have been utilized to investigate protein-DNA interactions in the transcription initiation and rDNA transcription termination regions of human mitochondrial DNA (mtDNA) in
Attardi, Giuseppe, Fernádez-Silva, Patricio, Micol, Vicente   +2 more
core   +1 more source