Results 71 to 80 of about 1,419,974 (304)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Morbid Obesity: An Obstetric Challenge

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Obesity, which has become a modern-day pandemic, is also compounding the problems of managing pregnant women. It affects the course of ante, intra and postpartum period of pregnancy.
Shabista Shaikh, Tanvi Nijhawan
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A Study on the Pattern of Arterial Segmentation in the Human Spleen

National Journal of Clinical Anatomy
Background: Partial splenectomy is preferred after splenic injuries, which will help to preserve healthy splenic tissue, hence the immunity. During splenic surgery particularly in the resection of a segment of the spleen, ligation of branches of the ...
Abdul Alim Ahmed, Rup Sekhar Deka
doaj   +1 more source

Inferring Termination Conditions for Logic Programs using Backwards Analysis

, 2003
This paper focuses on the inference of modes for which a logic program is guaranteed to terminate. This generalises traditional termination analysis where an analyser tries to verify termination for a specified mode.
Codish, Michael, Genaim, Samir
core   +2 more sources

Termination Casts: A Flexible Approach to Termination with General Recursion

, 2010
This paper proposes a type-and-effect system called Teqt, which distinguishes terminating terms and total functions from possibly diverging terms and partial functions, for a lambda calculus with general recursion and equality types.
A. Abel, A. Bove, A. Miquel, A. Stump, A. Stump, Aaron Stump, Ana Bove, B. Barras, C. Chen, E Pasalic, Ekaterina Komendantskaya, G. Barthe, K. Crary, L. Augustsson, M. Beeson, M. Sozeau, Milad Niqui, N. Mishra-Linger, P. Sewell, P. Wadler, S. Feferman, Stephanie Weirich, T. Sheard, V. Capretta, Vilhelm Sjöberg   +24 more
core   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decay

Cell Genomics
Summary: The phenotypic impact of nonsense variants is determined by nonsense-mediated mRNA decay (NMD), which degrades transcripts with premature termination codons (PTCs).
Divya Kolakada, Rui Fu, Nikita Biziaev, Alexey Shuvalov, Mlana Lore, Amy E. Campbell, Michael A. Cortázar, Marcin P. Sajek, Jay R. Hesselberth, Neelanjan Mukherjee, Elena Alkalaeva, Zeynep H. Coban-Akdemir, Sujatha Jagannathan   +12 more
doaj   +1 more source

Interface effects at a half-metal/ferroelectric junction

, 2007
Magnetoelectric effects are investigated ab-initio at the interface between half-metallic and ferroelectric prototypes: Heusler Co$_2$MnSi and perovskite BaTiO$_3$.
Picozzi, Silvia, Sanyal, Biplab, Yamauchi, Kunihiko   +2 more
core   +1 more source