Results 91 to 100 of about 658,465 (305)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Kanun, 2018 Berdasarkan Peraturan Bank Indonesia Nomor: 7/46/PBI/2005 tentang Akad Penghimpunan dan Penyaluran Dana Bagi Bank yang Melaksanakan Kegiatan Usaha berdasarkan Prinsip Syariah menyebutkan “Qard adalah suatu akad penyaluran dana oleh Bank Syariah atau Unit
Humaira Humaira
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Mobile termination, network externalities, and consumer expectations [PDF]
We re-examine the literature on mobile termination in the presence of network externalities. Externalities arise when firms discriminate between on- and off-net calls or when subscription demand is elastic.
Hurkens, Sjaak, Lopez, Angel
core
Encoding induction in correctness proofs of program transformations as a termination problem [PDF]
, 2012 The diagram-based method to prove correctness of program transformations consists of computing complete set of (forking and commuting) diagrams, acting on sequences of standard reductions and program transformations.
Sabel, David +2 more
core
Cellular mRNAs access second ORFs using a novel amino acid sequence-dependent coupled translation termination-reinitiation mechanism [PDF]
, 2014 Polycistronic transcripts are considered rare in the human genome. Initiation of translation of internal ORFs of eukaryotic genes has been shown to use either leaky scanning or highly structured IRES regions to access initiation codons.
Dyer, Nigel P. +4 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Is South African labour law for dismissal based on operational requirements unduly onerous for employers? [PDF]
, 2014 An international perspective on retrenchment based on the application of international labour standards (ILO 'Termination of Employment Convention 158' and ILO 'Termination of Employment Recommendation 166'
Levy, Emma
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Possibility of Restricting the Legal Remedies for Breach of Contract in the Case of Substantial Performance [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i KhuṣūṣīBased on the general principles of contract law, including the necessity of performing obligations and the binding force of contracts, the parties are assumed to fulfill their commitments only if they carry out all contractual obligations and conditions ...
Laya Joneydi, Sajjad Ghasemi
doaj +1 more source