Results 91 to 100 of about 1,419,974 (304)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Termination Detection of Local Computations
, 2009 Contrary to the sequential world, the processes involved in a distributed system do not necessarily know when a computation is globally finished. This paper investigates the problem of the detection of the termination of local computations.
Godard, Emmanuel +2 more
core +2 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
A Jurisprudential and Legal Study of the Effect of Termination Compared to Previous Contracts [PDF]
آموزههای فقه مدني, 2020 Traditionally, one of the distinguishing features of termination and annulment of a contract is considered to be that annulment makes the contract ineffective from the beginning, and termination has no effect on the past and makes the contract ...
Mahdi Chegeni +1 more
doaj
Polytool: polynomial interpretations as a basis for termination analysis of Logic programs
, 2009 Our goal is to study the feasibility of porting termination analysis techniques developed for one programming paradigm to another paradigm. In this paper, we show how to adapt termination analysis techniques based on polynomial interpretations - very ...
De Schreye, Danny +3 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Management of contractor's claim in Turnkey projects according to FIDIC under termination and dissolution of contract [PDF]
مهندسی و مدیریت ساخت, 2019 Generally, increasing complexity of the structural stages of the contracts and contracting conditions as well as inconvenient conditions of projects including Meteorological, political, and leads to intensification of disputes, claims and litigation ...
Amir Momeni, Mohsen Heidari
doaj
Improved shielding termination adapter for electrical cable connectors [PDF]
, 1970 Termination adapter replaces braid ring and ensures permanent attachment and grounding of sheath wires. The inner ferrule of the termination is slipped inside the exposed ends of the sheath wires and the outer ferrule is placed over the wires and crimped
Vanasse, M. A.
core +1 more source