Results 121 to 130 of about 4,731,740 (265)

Learning from pandemics: Feature selection and clustering for robust digital disease nowcasting. [PDF]

PLoS One
Mesquita S, Loureiro J, Haupt Vieira C, Perfeito L, Gonçalves-Sá J.   +4 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Shared molecular pathways in pediatric genetic epilepsies: Insights from a single-center cohort of 80 patients. [PDF]

Epilepsia Open
Hecher L, Woidy M, Plein F, Bierhals T, Elsner LV, Herget T, Hempel M, Kortüm F, Grinstein L, Cramer JV, Johannsen J, Denecke J.   +11 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The Growth and Trends in Cancer-Induced Cachexia Research: A Bibliometric and AI-Guided Visualization Analysis. [PDF]

Cancer Rep (Hoboken)
O'Connell TM, Gedela R, Pin F.
europepmc   +1 more source

On Term by Term Integration

On Term by Term Integration
application ...
openaire   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

PhenoSS: phenotype semantic similarity-based approach for rare disease prediction and patient clustering. [PDF]

J Am Med Inform Assoc
Chen S, Nguyen QM, Hu Y, Liu C, Weng C, Wang K.   +5 more
europepmc   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Umbrella review protocol of meta-analyses on intraoperative protective ventilation. [PDF]

BMJ Open
Song F, Wang M, Song S, Wan P.
europepmc   +1 more source