Results 81 to 90 of about 113,738 (266)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Ternary Logic Design Based on Novel Tunneling-Drift-Diffusion Field-Effect Transistors

Nanomaterials
In this paper, a novel Tunneling-Drift-Diffusion Field-Effect Transistor (TDDFET) based on the combination of the quantum tunneling and conventional drift-diffusion mechanisms is proposed for the design of ternary logic circuits. The working principle of
Bin Lu, Hua Qiang, Dawei Wang, Xiaojing Cui, Jiayu Di, Yuanhao Miao, Zhuofan Wang, Jiangang Yu   +7 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Self‐Catalyzed AlGaAs Nanowires and AlGaAs/GaAs Axial Heterostructures Grown by Molecular Beam Epitaxy

Advanced Materials Interfaces
Self‐catalyzed AlGaAs nanowires (NWs) offer advantageous properties, including lattice matching to GaAs, a wide range of electronic bandgaps, and monolithic integration with the mature Si platform due to elastic strain relaxation.
Giorgos Boras, Haotian Zeng, Stephen Church, Raghavendra Juluri, Anton Velichko, Huiwen Deng, Hui Jia, Francisco Alvarado, Ziyue Yin, Chong Chen, Jaeseong Park, Mingchu Tang, David Mowbray, Ana M. Sanchez, Patrick Parkinson, Huiyun Liu   +15 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Ternary Menger hyperalgebras: some algebraic properties

Қарағанды университетінің хабаршысы. Математика сериясы
In this article, we first establish an algebraic hyperstructure called a ternary Menger hyperalgebra of rank n, where n is a natural number. The algebraic hyperstructure can be regarded as a novel generalization of ternary semihypergroups. In particular,
A. Nongmanee, S. Leeratanavalee
doaj   +1 more source

Modeling the Transport and Volumetric Properties of Solutions Containing Polymer and Electrolyte with New Model [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2018
A new theoretical model based on the local composition concept (TNRF-mNRTL model) was proposed to express the short-range contribution of the excess Gibbs energy for the solutions containing polymer and electrolyte. This contribution of interaction along
Ali Mohammadian-Abriz, Roghayeh Majdan-Cegincara   +1 more
doaj  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

An RTL-Based General Synthesis Methodology for Device-Independent Ternary Logic Circuits

IEEE Access
Ternary logic circuits are considered a high-potential alternative that can continue the technological advance of binary logic. Current studies in ternary logic focus on two aspects: One focuses on designing specific ternary circuits (such as adders ...
Hanmok Park, Seonghoon Kim, Sunmean Kim, Taigon Song   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source