Results 1 to 10 of about 67,544 (332)

Computational identification of potential natural terpenoid inhibitors of MDM2 for breast cancer therapy: molecular docking, molecular dynamics simulation, and ADMET analysis [PDF]

Frontiers in Chemistry
BackgroundBreast cancer (BC) remains a leading cause of cancer-related mortality in women. The oncoprotein MDM2 negatively regulates the tumor suppressor p53, and its overexpression in BC promotes tumor progression and resistance to therapy.
Eva Azme, Md. Mahmudul Hasan, Md. Liakot Ali, Rashedul Alam, Rashedul Alam, Neamul Hoque, Fabiha Noushin, Mohammed Fazlul Kabir, Ashraful Islam, Tanzina Sharmin Nipun, S. M. Moazzem Hossen, Hea-Jong Chung, Hea-Jong Chung   +12 more
doaj   +2 more sources

Carvacrol, a Plant Metabolite Targeting Viral Protease (Mpro) and ACE2 in Host Cells Can Be a Possible Candidate for COVID-19

Frontiers in Plant Science, 2021
The recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started in December 2019, resulting in the coronavirus disease-19 (COVID-19) pandemic. Coronaviruses are solely accountable for rising mortality and socioeconomic saddles.
Hayate Javed, Mohamed Fizur Nagoor Meeran, Niraj Kumar Jha, Shreesh Ojha   +3 more
doaj   +1 more source

Characterizing Photosynthetic Biofuel Production: Isotopically Non-Stationary 13C Metabolic Flux Analysis on Limonene Producing Synechococcus sp. PCC 7002

Frontiers in Energy Research, 2022
Synechococcus sp. PCC 7002 is a unicellular cyanobacterium capable of fast growth and tolerance to high light intensity and high salinity. These attributes along with genetic tractability make Synechococcus sp.
Darrian M. Newman, Cara L. Sake, Alexander J. Metcalf, Fiona K. Davies, Melissa Cano, Anagha Krishnan, Nanette R. Boyle   +6 more
doaj   +1 more source

Multi-omics analysis the differences of VOCs terpenoid synthesis pathway in maintaining obligate mutualism between Ficus hirta Vahl and its pollinators

Frontiers in Plant Science, 2022
InroductionVolatile organic compounds (VOCs) emitted by the receptive syconia of Ficus species is a key trait to attract their obligate pollinating fig wasps.
Songle Fan, Songle Fan, Songle Fan, Yongxia Jia, Rong Wang, Xiaoyong Chen, Wanzhen Liu, Wanzhen Liu, Hui Yu, Hui Yu   +9 more
doaj   +1 more source

Metabolomics Analysis Reveals Drought Responses of Trifoliate Orange by Arbuscular Mycorrhizal Fungi With a Focus on Terpenoid Profile

Frontiers in Plant Science, 2021
Soil water deficit seriously affects crop production, and soil arbuscular mycorrhizal fungi (AMF) enhance drought tolerance in crops by unclear mechanisms.
Sheng-Min Liang, Fei Zhang, Fei Zhang, Ying-Ning Zou, Kamil Kuča, Qiang-Sheng Wu, Qiang-Sheng Wu   +6 more
doaj   +1 more source

AmMYB24 Regulates Floral Terpenoid Biosynthesis Induced by Blue Light in Snapdragon Flowers

Frontiers in Plant Science, 2022
Floral terpenoid volatiles are impacted by light quality. In snapdragon, blue light can significantly enhance the emissions of ocimene and myrcene and the expression of ocimene synthase (AmOCS) and myrcene synthase (AmMYS).
Jianing Han, Jianing Han, Tong Li, Tong Li, Xuelian Wang, Xuelian Wang, Xi Zhang, Xi Zhang, Xiaoning Bai, Xiaoning Bai, Huihui Shao, Huihui Shao, Shaojie Wang, Zenghui Hu, Zenghui Hu, Jing Wu, Jing Wu, Pingsheng Leng, Pingsheng Leng   +18 more
doaj   +1 more source

A Critical Evaluation of Terpenoid Signaling at Cannabinoid CB1 Receptors in a Neuronal Model

Molecules, 2022
In addition to phytocannabinoids, cannabis contains terpenoids that are claimed to have a myriad of effects on the body. We tested a panel of five common cannabis terpenoids, myrcene, linalool, limonene, α-pinene and nerolidol, in two neuronal models ...
Michaela Dvorakova, Sierra Wilson, Wesley Corey, Jenna Billingsley, Anaëlle Zimmowitch, Joye Tracey, Alex Straiker, Ken Mackie   +7 more
doaj   +1 more source

Isolation and Identification of Pentalenolactone Analogs from Streptomyces sp. NRRL S-4

Molecules, 2021
Terpene synthases are widely distributed in Actinobacteria. Genome sequencing of Streptomyces sp. NRRL S-4 uncovered a biosynthetic gene cluster (BGC) that putatively synthesizes pentalenolactone type terpenes.
Huanhuan Li, Hongji Li, Shuo Chen, Wenhui Wu, Peng Sun   +4 more
doaj   +1 more source

Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update

Applied Sciences, 2021
ROS, RNS, and carcinogenic metabolites generate excessive oxidative stress, which changes the basal cellular status and leads to epigenetic modification, genomic instability, and initiation of cancer.
Md Afjalus Siraj, Md. Arman Islam, Md. Abdullah Al Fahad, Habiba Rahman Kheya, Jianbo Xiao, Jesus Simal-Gandara   +5 more
doaj   +1 more source

Chemical Constituents and Their Biological Activities from Genus Styrax

Pharmaceuticals, 2023
Plants from the genus Styrax have been extensively used in folk medicines to treat diseases such as skin diseases and peptic ulcers and as an antiseptic and analgesic.
Ding-Ding Xia, Xin-Yu Han, Yu Zhang, Na Zhang   +3 more
doaj   +1 more source